J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
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Journal ArticleDOI
Sequestration of RNA in Alzheimer's disease neurofibrillary tangles and senile plaques
TL;DR: Quantitative analysis of double‐labeled sections demonstrated that approximately 80% of TS‐positive NFTs also were AO‐positive, whereas approximately 55% ofTS‐stained SPs contained AO labeling, demonstrating the relative specificity of AO for RNA species.
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Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy
Naomi Kouri,Owen A. Ross,Beth A. Dombroski,Curtis S. Younkin,Daniel J. Serie,Alexandra I. Soto-Ortolaza,Matthew C. Baker,Ni Cole A. Finch,Hyejin Yoon,Jungsu Kim,Shinsuke Fujioka,Catriona McLean,Bernardino Ghetti,Salvatore Spina,Laura B. Cantwell,Martin R. Farlow,Jordan Grafman,Edward D. Huey,Mi Ryung Han,Sherry Beecher,Evan T. Geller,Hans A. Kretzschmar,Sigrun Roeber,Marla Gearing,Jorge L. Juncos,Jean Paul Vonsattel,Vivianna M. Van Deerlin,Murray Grossman,Howard I. Hurtig,Rachel Goldmann Gross,Steven E. Arnold,John Q. Trojanowski,Virginia M.-Y. Lee,Gregor K. Wenning,Charles L. White,Günter U. Höglinger,Günter U. Höglinger,Günter U. Höglinger,Ulrich Müller,Bernie Devlin,Lawrence I. Golbe,Julia E. Crook,Joseph E. Parisi,Bradley F. Boeve,Keith A. Josephs,Zbigniew K. Wszolek,Ryan J. Uitti,Neill R. Graff-Radford,Irene Litvan,Steven G. Younkin,Li-San Wang,Nilufer Ertekin-Taner,Rosa Rademakers,Hakon Hakonarsen,Gerard D. Schellenberg,Dennis W. Dickson +55 more
TL;DR: A genome-wide association study (GWAS) in CBD cases (n=152) and 3,311 controls, and 67 CBD cases and 439 controls in a replication stage was conducted in this article.
Journal ArticleDOI
Alpha-synuclein-induced aggregation of cytoplasmic vesicles in Saccharomyces cerevisiae.
James H. Soper,Subhojit Roy,Anna Stieber,Eliza Lee,Robert B. Wilson,John Q. Trojanowski,Christopher G. Burd,Virginia M.-Y. Lee +7 more
TL;DR: In this article, the authors provided ultrastructural evidence that alpha-syn accumulations are not comprised of Lewy bodies, but are associated with clusters of vesicles, and they used live-cell imaging to reveal the molecular determinants and vesicular trafficking pathways underlying this pathological process.
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Evaluation of Potential Infectivity of Alzheimer and Parkinson Disease Proteins in Recipients of Cadaver-Derived Human Growth Hormone
David J. Irwin,Joseph Y. Abrams,Lawrence B. Schonberger,Ellen W. Leschek,James L. Mills,Virginia M.-Y. Lee,John Q. Trojanowski +6 more
TL;DR: In this unique in vivo model of human-to-human transmission, there is no evidence to support concerns that NDAPs underlying AD and PD transmit disease in humans despite evidence of their cell- to-cell transmission in model systems of these disorders.
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Clinical and multimodal biomarker correlates of ADNI neuropathological findings
Jon B. Toledo,Nigel J. Cairns,Xiao Da,Kewei Chen,Deborah Carter,Adam S. Fleisher,Erin Householder,Napatkamon Ayutyanont,Auttawut Roontiva,Robert Bauer,Paul Eisen,Leslie M. Shaw,Christos Davatzikos,Michael W. Weiner,Eric M. Reiman,John C. Morris,John Q. Trojanowski +16 more
TL;DR: Biomarkers can be used to independently predict coincident AD and DLB pathology, a common finding in amnestic MCI and DAT patients, and subjects with coincident MTL showed lower hippocampal volume.