John Q. Trojanowski

TL;DR: Unlike the CSF biomarkers evaluated, changes in serial structural MRI are correlated with concurrent change on general cognitive and functional indices in impaired subjects, track with clinical disease stage, and are influenced by APOE genotype.

TL;DR: By using these highly specific anti-parkin monoclonal antibodies, it was not possible to detect parkin in α-synuclein-containing lesions inα- synucleinopathies, thereby challenging prior inferences about the role of Parkin in movement disorders other than autosomal recessive juvenile parkinsonism.

TL;DR: A paradigm shift in understanding Parkinson's disease and related disorders is emerging from studies showing that alpha-synuclein (AS) gene mutations cause familial PD; AS is abnormally nitrated, phosphorylated, and ubiquitinated; AS forms neuronal and glial inclusions; AS fibrillizes in vitro; and AS transgenic animals develop neurodegeneration with AS amyloid inclusions as discussed by the authors.

TL;DR: An association between altered BA profile, genetic variants implicated in AD and cognitive changes in disease is reported using a large multicenter study and warrant further investigation of gut dysbiosis and possible role of gut liver brain axis in the pathogenesis of AD.

TL;DR: Assessment of sensorimotor gating could be used to detect the earliest manifestations of tauopathies exemplified by prodromal AD, in which abnormal tau protein may play critical roles in the onset of neuronal dysfunctions.