John Q. Trojanowski

TL;DR: A large number of plasma‐based biomarkers were sought for CI in PD and the timing of onset nor the severity of cognitive symptoms can be accurately predicted.

TL;DR: To characterize sequential patterns of regional neuropathology and clinical symptoms in a well‐characterized cohort of 21 patients with autopsy‐confirmed Pick disease, sequential patterns in clinical symptoms are characterized.

TL;DR: Although clinically heterogeneous, CBD is a distinct lobar and basal ganglionic tauopathy with selective aggregation of 4R-tau with similar burden of tau abnormalities in frontal, temporal, and parietal lobes and basal Ganglia of both hemispheres.

TL;DR: High-resolution ex vivo MRI scans of 31 human hippocampal specimens are combined using a groupwise diffeomorphic registration approach into a 3D probabilistic atlas that captures average anatomy and anatomic variability of hippocampal subfields, finding three-dimensional patterns of variability and disease and aging effects discovered via the ex vivo hippocampus atlas.

TL;DR: In this article, heat shock proteins (Hsps) facilitate refolding of denatured polypeptides, but there is limited understanding about their roles in neurodegenerative diseases characterized by misfolded proteins.