J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
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Journal Article
Phenotypic and Genotypic Analysis of a Human Medulloblastoma Cell Line and Transplantable Xenograft (D341 Med) Demonstrating Amplification of c-myc
Henry S. Friedman,Peter C. Burger,S. H. Bigner,John Q. Trojanowski,Garrett M. Brodeur,Xuanmin He,Carol J. Wikstrand,Joanne Kurtzberg,M E Berens,Edward C. Halperin +9 more
TL;DR: This cell line and transplantable xenograft may allow, in conjunction with the authors' other models of human medulloblastoma, analysis of the heterogeneous biologic properties and therapeutic sensitivity of this tumor.
Journal ArticleDOI
IBOX(2-(4'-dimethylaminophenyl)-6-iodobenzoxazole): a ligand for imaging amyloid plaques in the brain.
Zhi-Ping Zhuang,Mei-Ping Kung,Catherine Hou,Karl Plössl,Daniel M. Skovronsky,Tamar L. Gur,John Q. Trojanowski,Virginia M.-Y. Lee,Hank F. Kung +8 more
TL;DR: It is predicted that the brain trapping of this new radioiodinated ligand in the Abeta containing regions will be more favorable than that of the parent compound, [125I]TZDM.
Journal ArticleDOI
PART, a distinct tauopathy, different from classical sporadic Alzheimer disease
Kurt A. Jellinger,Irina Alafuzoff,Johannes Attems,Thomas G. Beach,Nigel J. Cairns,John F. Crary,Dennis W. Dickson,Patrick R. Hof,Bradley T. Hyman,Clifford R. Jack,Gregory A. Jicha,David S. Knopman,Gabor G. Kovacs,Ian R. A. Mackenzie,Eliezer Masliah,Thomas J. Montine,Peter T. Nelson,Frederick A. Schmitt,Julie A. Schneider,Albert Serrano-Pozo,Dietmar Rudolf Thal,Jonathan B. Toledo,John Q. Trojanowski,Juan C. Troncoso,Jean Paul G. Vonsattel,Thomas Wisniewski +25 more
TL;DR: No elevated soluble Aβ was detected in primary age-related tauopathy and this disorder has been referred to as tangle-predominant senile dementia (TPSD) or “tangle-only dementia”.
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Interactions between Hsp70 and the hydrophobic core of alpha-synuclein inhibit fibril assembly.
TL;DR: In vitro assembly of alpha-Syn fibril assembly was efficiently inhibited by substoichiometric concentrations of purified Hsp70 in the absence of cofactors, suggesting that this critical step in Parkinson's disease pathogenesis may be subject to modulation by a common molecular chaperone.
Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy
Naomi Kouri,Owen A. Ross,Beth A. Dombroski,Curtis S. Younkin,Daniel J. Serie,Alexandra I. Soto-Ortolaza,Matthew C. Baker,Ni Cole A. Finch,Hyejin Yoon,Jungsu Kim,Shinsuke Fujioka,Catriona McLean,Bernardino Ghetti,Salvatore Spina,Laura B. Cantwell,Martin R. Farlow,Jordan Grafman,Edward D. Huey,Mi Ryung Han,Sherry Beecher,Evan T. Geller,Hans A. Kretzschmar,Sigrun Roeber,Marla Gearing,Jorge L. Juncos,Jean Paul Vonsattel,Vivianna M. Van Deerlin,Murray Grossman,Howard I. Hurtig,Rachel Goldmann Gross,Steven E. Arnold,John Q. Trojanowski,Virginia M.-Y. Lee,Gregor K. Wenning,Charles L. White,Günter U. Höglinger,Günter U. Höglinger,Günter U. Höglinger,Ulrich Müller,Bernie Devlin,Lawrence I. Golbe,Julia E. Crook,Joseph E. Parisi,Bradley F. Boeve,Keith A. Josephs,Zbigniew K. Wszolek,Ryan J. Uitti,Neill R. Graff-Radford,Irene Litvan,Steven G. Younkin,Li-San Wang,Nilufer Ertekin-Taner,Rosa Rademakers,Hakon Hakonarsen,Gerard D. Schellenberg,Dennis W. Dickson +55 more
TL;DR: A genome-wide association study in CBD cases and controls shows that CBD and PSP share a genetic risk factor other than MAPT at 3p22 MOBP (myelin-associated oligodendrocyte basic protein).