J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
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Journal Article
Oxidative stress, mutant SOD1, and neurofilament pathology in transgenic mouse models of human motor neuron disease
TL;DR: Recent insights into mechanisms of motor neuron degeneration in ALS that have emerged from studies of these new animal models of this neurodegenerative disease are summarized.
Journal ArticleDOI
Extensive FUS‐Immunoreactive Pathology in Juvenile Amyotrophic Lateral Sclerosis with Basophilic Inclusions
Eric J. Huang,Jiasheng Zhang,Felix Geser,John Q. Trojanowski,Jonathan B. Strober,Dennis W. Dickson,Robert H. Brown,Barbara E. Shapiro,Catherine Lomen-Hoerth +8 more
TL;DR: This study represents the first detailed characterizations of neuropathological findings in rapidly progressive juvenile ALS patients with a mutation in the FUS/TLS gene and underscores the importance of FUS mutations and pathology in rapidlygressive juvenile ALS.
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Association of Altered Liver Enzymes With Alzheimer Disease Diagnosis, Cognition, Neuroimaging Measures, and Cerebrospinal Fluid Biomarkers.
Kwangsik Nho,Alexandra Kueider-Paisley,Shahzad Ahmad,Siamak MahmoudianDehkordi,Matthias Arnold,Shannon L. Risacher,Gregory Louie,Colette Blach,Rebecca Baillie,Xianlin Han,Gabi Kastenmüller,John Q. Trojanowski,Leslie M. Shaw,Michael W. Weiner,P. Murali Doraiswamy,Cornelia M. van Duijn,Cornelia M. van Duijn,Andrew J. Saykin,Rima Kaddurah-Daouk +18 more
TL;DR: In this paper, the authors examined whether liver function markers are associated with cognitive dysfunction and the A/T/N (amyloid, tau, and neurodegeneration) biomarkers for AD.
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Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology
Erik Portelius,Erik Portelius,Bob Olsson,Bob Olsson,Kina Höglund,Kina Höglund,Nicholas C. Cullen,Hlin Kvartsberg,Ulf Andreasson,Ulf Andreasson,Henrik Zetterberg,Åsa Sandelius,Leslie M. Shaw,Virginia M.-Y. Lee,David J. Irwin,Murray Grossman,Daniel Weintraub,Daniel Weintraub,Alice Chen-Plotkin,David A. Wolk,Leo McCluskey,Lauren Elman,Jennifer D. McBride,Jon B. Toledo,Jon B. Toledo,John Q. Trojanowski,Kaj Blennow,Kaj Blennow +27 more
TL;DR: It is shown that Ng significantly increased the discrimination between AD and several other disorders, and that high CSF Ng concentrations likely reflect synaptic dysfunction and thatCSF Ng is associated with β-amyloid plaque pathology.
Journal ArticleDOI
Integration and relative value of biomarkers for prediction of MCI to AD progression: spatial patterns of brain atrophy, cognitive scores, APOE genotype and CSF biomarkers.
Xiao Da,Jon B. Toledo,Jarcy Zee,David A. Wolk,Sharon X. Xie,Yangming Ou,Amanda Shacklett,Paraskevi Parmpi,Leslie M. Shaw,John Q. Trojanowski,Christos Davatzikos +10 more
TL;DR: The findings suggest that SPARE-AD and ADAS-Cog in combination offer the highest predictive power of conversion from MCI to AD, which is improved, albeit not significantly, by APOE genotype.