J
John R. Corboy
Researcher at University of Colorado Boulder
Publications - 116
Citations - 5194
John R. Corboy is an academic researcher from University of Colorado Boulder. The author has contributed to research in topics: Multiple sclerosis & Medicine. The author has an hindex of 32, co-authored 107 publications receiving 4624 citations. Previous affiliations of John R. Corboy include University of Montana & University of Otago.
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Journal ArticleDOI
Neuromyelitis optica brain lesions localized at sites of high aquaporin 4 expression.
Sean J. Pittock,Brian G. Weinshenker,Claudia F. Lucchinetti,Dean M. Wingerchuk,John R. Corboy,Vanda A. Lennon +5 more
TL;DR: The distribution of NMO-characteristic brain lesions corresponds to sites of high AQP4 expression in mammalian brain, and recurring and distinctive magnetic resonance imaging abnormalities in the hypothalamic and periventricular areas that corresponded to brain regions ofhigh AQP 4 expression are observed.
Journal ArticleDOI
Oral simvastatin treatment in relapsing-remitting multiple sclerosis.
Timothy Vollmer,L. Lyndon Key,Valerie Durkalski,William R. Tyor,William R. Tyor,John R. Corboy,John R. Corboy,Silva Markovic-Plese,Jana Lizrova Preiningerova,Jana Lizrova Preiningerova,Marco A. Rizzo,Inderjit Singh +11 more
TL;DR: Investigation of use of oral simvastatin in 30 individuals with relapsing-remitting multiple sclerosis found it to inhibit inflammatory components of multiple sclerosis that lead to neurological disability.
Journal ArticleDOI
Factors that influence adherence with disease-modifying therapy in MS.
Katherine Treadaway,Gary Cutter,Amber Salter,Sharon G. Lynch,James Simsarian,John R. Corboy,Douglas Jeffery,Bruce A. Cohen,Ken Mankowski,Joseph Guarnaccia,Lawrence Schaeffer,Roy Kanter,David Brandes,Charles K. Kaufman,David Duncan,Ellen Marder,Arthur Allen,John Harney,Joanna Cooper,Douglas Woo,Olaf Stüve,Michael K. Racke,Elliot M. Frohman +22 more
TL;DR: This study characterizes factors that are associated with failure to fully adhere with disease modifying injection therapy for MS and underscores the principles associated with optimizing adherence and its implications for effective treatment of the disease process in MS.
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High-dose immunosuppressive therapy and autologous peripheral blood stem cell transplantation for severe multiple sclerosis.
Richard A. Nash,James D. Bowen,Peter A. McSweeney,Steven Z. Pavletic,Kenneth R. Maravilla,Man Soo Park,Jan Storek,Keith M. Sullivan,Jinan Al-Omaishi,John R. Corboy,John F. DiPersio,George E. Georges,Ted Gooley,Leona Holmberg,C. Fred LeMaistre,Kate Ryan,Harry Openshaw,Julie Sunderhaus,Rainer Storb,Joseph R. Zunt,George H. Kraft +20 more
TL;DR: Important clinical issues in the use of HDIT and stem cell transplantation for MS were identified; however, modifications of the initial approaches appear to reduce treatment risks.
Journal ArticleDOI
Single-Cell Repertoire Analysis Demonstrates that Clonal Expansion Is a Prominent Feature of the B Cell Response in Multiple Sclerosis Cerebrospinal Fluid
Gregory P. Owens,Alanna M. Ritchie,Mark P. Burgoon,R. Anthony Williamson,John R. Corboy,Donald H. Gilden +5 more
TL;DR: Single-cell RT-PCR was used to sample CD19+ B cell repertoires in cerebrospinal fluid of patients with multiple sclerosis (MS) or viral meningitis to identify the rearranged germline segment and J segment, and the degree of homology for the H and L chain sequence of individual B cells.