J
John R. Jimah
Researcher at National Institutes of Health
Publications - 21
Citations - 854
John R. Jimah is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Dynamin & Endocytosis. The author has an hindex of 8, co-authored 19 publications receiving 562 citations. Previous affiliations of John R. Jimah include State University of New York Upstate Medical University & University of South Florida.
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N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: A randomized, double-blind, placebo-controlled trial
Zhi-Wei Lai,Robert Hanczko,Eduardo Bonilla,Tiffany Caza,Brandon Clair,Adam Bartos,Gabriella Miklossy,John R. Jimah,Edward Doherty,Hajra Tily,Lisa Francis,Ricardo Garcia,Maha Dawood,Jianghong Yu,Irene Ramos,Ioana L. Coman,Stephen V. Faraone,Paul E. Phillips,Andras Perl +18 more
TL;DR: This pilot study suggests that NAC safely improves lupus disease activity by blocking mTOR in T lymphocytes by blocking rapamycin by glutathione in patients with SLE.
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Rhoptry Proteins ROP5 and ROP18 Are Major Murine Virulence Factors in Genetically Divergent South American Strains of Toxoplasma gondii.
Michael S. Behnke,Asis Khan,Elvin J. Lauron,John R. Jimah,Qiuling Wang,Niraj H. Tolia,L. David Sibley +6 more
TL;DR: ROP5 and ROP18 are conserved virulence factors in genetically diverse strains from North and South America, suggesting they evolved to resist innate immune defenses in ancestral T. gondii strains, and they have subsequently diversified under positive selection.
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Structural Insights into the Mechanism of Dynamin Superfamily Proteins
John R. Jimah,Jenny E. Hinshaw +1 more
TL;DR: In this review, the current understanding of the molecular mechanism of DSPs is summarized, with emphasis on the structural basis of function.
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Isoprenoid biosynthesis inhibition disrupts Rab5 localization and food vacuolar integrity in Plasmodium falciparum.
TL;DR: In conclusion, fosmidomycin treatment caused marked defects in food vacuolar morphology and integrity, consistent with a defect in Rab-mediated vesicular trafficking, which may assist the rational selection of secondary agents that will be useful in combination therapy with new isoprenoid biosynthesis inhibitors.
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Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein
Ruihui Zhang,Dong-Hoon Lee,John R. Jimah,Nathalie Gerassimov,Changsong Yang,Sangjoon Kim,Delgermaa Luvsanjav,Jonathan D. Winkelman,Marcel Mettlen,Michael E. Abrams,Raghav Kalia,Peter Keene,Pratima Pandey,Benjamin Ravaux,Ji Hoon Kim,Jonathon A. Ditlev,Guofeng Zhang,Michael K. Rosen,Adam Frost,Neal M. Alto,Margaret L. Gardel,Sandra L. Schmid,Tatyana Svitkina,Jenny E. Hinshaw,Elizabeth H. Chen,Elizabeth H. Chen +25 more
TL;DR: D dynamin forms a helical structure with actin and, upon disruption, enhances branched actin polymerization, constituting a dynamic cycle to regulate actin cytoskeleton mechanical strength.