J
John R. Prowle
Researcher at Queen Mary University of London
Publications - 187
Citations - 7968
John R. Prowle is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Acute kidney injury & Renal replacement therapy. The author has an hindex of 39, co-authored 161 publications receiving 5248 citations. Previous affiliations of John R. Prowle include Royal London Hospital & Austin Hospital.
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Journal ArticleDOI
Low avidity recognition of self-antigen by T cells permits escape from central tolerance
George Y. Liu,Paul J. Fairchild,Richard M. Smith,John R. Prowle,Dimitris Kioussis,David C. Wraith +5 more
TL;DR: This work has addressed the hypothesis that the avidity of T cell recognition in the thymus may be compromised, enabling autoreactive T cells to escape self-tolerance by constructing transgenic mice expressing an encephalitogenic T cell receptor (TCR) by using analogs of intermediate affinity.
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COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup.
Mitra K. Nadim,Lui G. Forni,Lui G. Forni,Ravindra L. Mehta,Michael J. Connor,Kathleen D. Liu,Marlies Ostermann,Thomas Rimmelé,Alexander Zarbock,Samira Bell,Azra Bihorac,Vincenzo Cantaluppi,Eric Hoste,Faeq Husain-Syed,Michael J. Germain,Stuart L. Goldstein,Shruti Gupta,Michael Joannidis,Kianoush Kashani,Jay L. Koyner,Matthieu Legrand,Nuttha Lumlertgul,Sumit Mohan,Neesh Pannu,Zhiyong Peng,Xose L. Perez-Fernandez,Peter Pickkers,John R. Prowle,Thiago Reis,Nattachai Srisawat,Nattachai Srisawat,Ashita Tolwani,Anitha Vijayan,Gianluca Villa,Li Yang,Claudio Ronco,John A. Kellum +36 more
TL;DR: This Consensus Statement from the Acute Disease Quality Initiative provides recommendations for the diagnosis, prevention and management of COVID-19 AKI and for areas of future research, with the aim of improving understanding of the underlying processes and outcomes for patients with CO VID- 19 AKI.
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Fluid balance and acute kidney injury
TL;DR: How interstitial edema can further delay renal recovery and why conservative fluid strategies are now being advocated are discussed and how accurate assessment of fluid status and careful definition of targets are needed at all stages to improve clinical outcomes are discussed.
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Clinical course and outcome of 107 patients infected with the novel coronavirus, SARS-CoV-2, discharged from two hospitals in Wuhan, China.
Dawei Wang,Yimei Yin,Chang Hu,Xing Liu,Xingguo Zhang,Shuliang Zhou,Mingzhi Jian,Haibo Xu,John R. Prowle,Bo Hu,Yirong Li,Zhiyong Peng +11 more
TL;DR: A period of 7–13 days after illness onset is the critical stage in the COVID-19 course, which shows persistent lymphopenia, severe acute respiratory dyspnea syndrome, refractory shock, anuric acute kidney injury, coagulopathy, thrombocytopenia, and death.
Journal ArticleDOI
Renal recovery after acute kidney injury.
Lui G. Forni,Lui G. Forni,Michael Darmon,Marlies Ostermann,H. M. Oudemans-van Straaten,Ville Pettilä,John R. Prowle,Miet Schetz,Michael Joannidis +8 more
TL;DR: The epidemiology of renal recovery, of the association between AKI and the development of CKD, and the importance of post-discharge follow-up of AKI patients and suggestions for its incorporation into clinical practice are reviewed.