J
John R. Walker
Researcher at Novartis
Publications - 32
Citations - 9535
John R. Walker is an academic researcher from Novartis. The author has contributed to research in topics: Gene expression profiling & Regulation of gene expression. The author has an hindex of 26, co-authored 32 publications receiving 8962 citations. Previous affiliations of John R. Walker include Genomics Institute of the Novartis Research Foundation.
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Journal ArticleDOI
A gene atlas of the mouse and human protein-encoding transcriptomes
Andrew I. Su,Tim Wiltshire,Serge Batalov,Hilmar Lapp,Keith A. Ching,David Block,Jie Zhang,Richard Soden,Mimi Hayakawa,Gabriel Kreiman,Gabriel Kreiman,Michael P. Cooke,John R. Walker,John B. Hogenesch,John B. Hogenesch +14 more
TL;DR: In this paper, high-density oligonucleotide arrays offer the opportunity to examine patterns of gene expression on a genome scale, and the authors have designed custom arrays that interrogate the expression of the vast majority of proteinencoding human and mouse genes and have used them to profile a panel of 79 human and 61 mouse tissues.
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Large-scale analysis of the human and mouse transcriptomes
Andrew I. Su,Michael P. Cooke,Keith A. Ching,Yaron Hakak,John R. Walker,Tim Wiltshire,Anthony P. Orth,Raquel Vega,Lisa M. Sapinoso,Aziz Moqrich,Ardem Patapoutian,Garret M. Hampton,Peter G. Schultz,Peter G. Schultz,John B. Hogenesch +14 more
TL;DR: This work generated and analyzed gene expression from 91 human and mouse samples across a diverse array of tissues, organs, and cell lines to reveal insights into molecular and physiological gene function, mechanisms of transcriptional regulation, disease etiology, and comparative genomics.
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Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells
Anthony E. Boitano,Jian Wang,Russell Romeo,Laure C. Bouchez,Albert E. Parker,Sue E. Sutton,John R. Walker,Colin A. Flaveny,Gary H. Perdew,Michael S. Denison,Peter G. Schultz,Michael P. Cooke +11 more
TL;DR: Mechanistic studies show that SR1 acts by antagonizing the aryl hydrocarbon receptor (AHR) and AHR modulation as a means to induce ex vivo HSC expansion should facilitate the clinical use of HSC therapy.
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cAMP promotes pancreatic β-cell survival via CREB-mediated induction of IRS2
Ulupi S. Jhala,Gianluca Canettieri,Robert A. Screaton,Rohit N. Kulkarni,Stan Krajewski,John C. Reed,John R. Walker,Xueying Lin,Morris F. White,Marc Montminy +9 more
TL;DR: It is shown that mice deficient in the activity of CREB, caused by expression of a dominant-negative A-CREB transgene in pancreatic β-cells, develop diabetes secondary to β-cell apoptosis, a novel mechanism by which opposing pathways cooperate in promoting cell survival.
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Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation
Brooke H. Miller,Erin L. McDearmon,Satchidananda Panda,Kevin R. Hayes,Kevin R. Hayes,Jie Zhang,Jessica L. Andrews,Marina P. Antoch,John R. Walker,Karyn A. Esser,John B. Hogenesch,John B. Hogenesch,Joseph S. Takahashi +12 more
TL;DR: It is found that the Clock mutation affects the expression of many genes that are rhythmic in WT tissue, but also profoundly affects many nonrhythmic genes, suggesting that tissue-specific output of the pacemaker is regulated in part by a transcriptional cascade.