J
John S. Ramsdell
Researcher at National Ocean Service
Publications - 115
Citations - 4232
John S. Ramsdell is an academic researcher from National Ocean Service. The author has contributed to research in topics: Domoic acid & Brevetoxin. The author has an hindex of 39, co-authored 115 publications receiving 4038 citations. Previous affiliations of John S. Ramsdell include Harvard University & National Marine Fisheries Service.
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Development and preliminary validation of a microtiter plate-based receptor binding assay for paralytic shellfish poisoning toxins
TL;DR: The findings indicate that the receptor binding assay has a strong predictive value for toxicity determined by mouse bioassay, and that this approach warrants consideration as a rapid, reliable and cost-effective alternative to live animal testing for detection and estimation of PSP-related toxicity in seafood and toxic algae.
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Cytotoxic and cytoskeletal effects of azaspiracid-1 on mammalian cell lines.
Michael J. Twiner,Philipp Hess,Marie-Yasmine Bottein Dechraoui,Terry McMahon,Melissa S. Samons,Melissa S. Samons,Masayuki Satake,Takeshi Yasumoto,John S. Ramsdell,Gregory J. Doucette +9 more
TL;DR: There were dramatic effects of AZA-1 on the arrangement of F-actin with the concurrent loss of pseudopodia, cytoplasmic extensions that function in mobility and chemotaxis, and further work using cell-based approaches is needed to determine the precise mode of action of AZa-1.
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Three activators of protein kinase C, bryostatins, dioleins, and phorbol esters, show differing specificities of action on GH4 pituitary cells.
TL;DR: It is proposed that different activators of protein kinase C (such as bryostatins, dioleins, and phorbol esters) may elicit different cellular responses by altering the substrate specificity or activating multiple forms of the kinase.
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Permanent and functional male-to-female sex reversal in d-rR strain medaka (Oryzias latipes) following egg microinjection of o,p'-DDT.
TL;DR: Results clearly indicate that a weakly estrogenic pesticide, o, p'-DDT, when presented during the critical period of gonadal development, can profoundly alter sexual differentiation in fish.
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Sexual dimorphism of brain aromatase activity in medaka: induction of a female phenotype by estradiol.
Ana Clara Melo,John S. Ramsdell +1 more
TL;DR: The results indicate that a positive feedback mechanism regulates brain aromatase and imply that the sexual dimorphic distribution of aromatases may be highly sensitive to physiologic cues and environmental perturbations in fish.