J
John Sondek
Researcher at University of North Carolina at Chapel Hill
Publications - 124
Citations - 12386
John Sondek is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: GTPase & Guanine nucleotide exchange factor. The author has an hindex of 54, co-authored 120 publications receiving 11610 citations. Previous affiliations of John Sondek include University of Pennsylvania & University of Medicine and Dentistry of New Jersey.
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Journal ArticleDOI
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
TL;DR: With 69 distinct homologues, Dbl-related GEFs represent the largest family of direct activators of Rho GTPases in humans, and they activate RhoGTPases within particular spatio-temporal contexts.
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The 2.0 Å crystal structure of a heterotrimeric G protein
TL;DR: The structure of a heterotrimeric G protein reveals the mechanism of the nucleotide-dependent engagement of the α and βγ subunits that regulates their interaction with receptor and effector molecules.
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Crystal structure of a G-protein beta gamma dimer at 2.1A resolution
TL;DR: The crystal structure of the βγ dimer of the G protein transducin is solved using multiwavelength anomalous diffraction data to solve the interactions between G protein β- and γ-subunits and highlights regions implicated in effector modulation for the conserved family of G proteinβγ dimers.
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GTPase Mechanism of Gproteins From the 1.7-A Crystal Structure of Transducin alpha-GDP-AIF-4
TL;DR: In this article, the crystal structure of transducin a o GDP acti-vated with aluminium fluoride (Gtα·GDP·A1F−4·H2O) at 1.7 A was derived from three independent representations in the asymmetric unit.
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Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1.
TL;DR: The Tiam1/Rac1 structure highlights the interactions that catalyse nucleotide exchange on RhoFamily G proteins, and illustrates structural determinants dictating specificity between individual Rho family members and their associated Dbl-related guanine nucleotide Exchange factors.