J
John Todd
Researcher at NHS Tayside
Publications - 65
Citations - 10219
John Todd is an academic researcher from NHS Tayside. The author has contributed to research in topics: RNA & Viral load. The author has an hindex of 30, co-authored 60 publications receiving 9843 citations. Previous affiliations of John Todd include Bayer & Glenfield Hospital.
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Journal ArticleDOI
Prognosis in HIV-1 Infection Predicted by the Quantity of Virus in Plasma
John W. Mellors,Charles R. Rinaldo,Phalguni Gupta,Roseanne M. White,John Todd,Lawrence A. Kingsley +5 more
TL;DR: Plasma viral load was a better predictor of progression to AIDS and death than was the number of CD4+ T cells, and the risk of acquired immunodeficiency syndrome (AIDS) and death in study subjects was directly related to plasma viral load at study entry.
Journal ArticleDOI
Plasma Viral Load and CD4+ Lymphocytes as Prognostic Markers of HIV-1 Infection
John W. Mellors,Alvaro Muñoz,Janis V. Giorgi,Joseph B. Margolick,Charles J. Tassoni,Phalguni Gupta,Lawrence A. Kingsley,John Todd,Alfred J. Saah,Roger Detels,John P. Phair,Charles R. Rinaldo +11 more
TL;DR: This study compared the prognostic value of plasma viral load with that of clinical, serologic, and cellular markers in a large cohort of HIV-infected men and incorporated the two most predictive markers-plasma viral load and CD4+ lymphocyte count-into a regression tree that is useful for assessing the prognosis of individual patients.
Journal ArticleDOI
Quantitation of HIV-1 RNA in Plasma Predicts Outcome after Seroconversion
John W. Mellors,Lawrence A. Kingsley,Charles R. Rinaldo,John Todd,Brad S. Hoo,Robert Kokka,Phalguni Gupta +6 more
TL;DR: The objective was to compare plasma HIV-1 RNA with determinations of serum p24 antigen, neopterin, and 2-microglobulin levels and CD4+ T-cell counts as predictors of outcome in a cohort of homosexual men with documented HIV- 1 seroconversion.
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Maternal Viral Load, Zidovudine Treatment, and the Risk of Transmission of Human Immunodeficiency Virus Type 1 from Mother to Infant
Rhoda S. Sperling,David Shapiro,Robert W. Coombs,John Todd,Steven A. Herman,George D. McSherry,Mary Jo O'Sullivan,Russell B. Van Dyke,Eleanor Jimenez,Christine Rouzioux,Patricia M. Flynn,John L. Sullivan,Stephen A. Spector,Clemente Diaz,James F. Rooney,James Balsley,Richard D. Gelber,Edward M. Connor +17 more
TL;DR: A placebo-controlled trial has shown that treatment with zidovudine reduces the rate at which human immunodeficiency virus type 1 (HIV-1) is transmitted from mother to infant as discussed by the authors.
Journal ArticleDOI
Ultrasensitive Flow-based Immunoassays Using Single-Molecule Counting
TL;DR: The Erenna IA-based technology reproducibly measures protein biomarkers with detection limits of 10-100 pg/L, with a dynamic range of >4.5 logs in sample volumes of 50-150 microL.