J
John W. Funder
Researcher at Hudson Institute of Medical Research
Publications - 399
Citations - 21486
John W. Funder is an academic researcher from Hudson Institute of Medical Research. The author has contributed to research in topics: Aldosterone & Mineralocorticoid. The author has an hindex of 74, co-authored 397 publications receiving 20195 citations. Previous affiliations of John W. Funder include Baker IDI Heart and Diabetes Institute & The Heart Research Institute.
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Journal ArticleDOI
The Management of Primary Aldosteronism: Case Detection, Diagnosis, and Treatment: An Endocrine Society Clinical Practice Guideline
John W. Funder,Robert M. Carey,Franco Mantero,M. Hassan Murad,Martin Reincke,Hirotaka Shibata,Michael Stowasser,William F. Young +7 more
TL;DR: This guideline recommends that all patients with primary aldosteronism undergo adrenal computed tomography as the initial study in subtype testing and to exclude adrenocortical carcinoma and advises that an experienced radiologist should establish/exclude unilateral primary aldehydes using bilateral adrenal venous sampling.
Journal ArticleDOI
Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated
TL;DR: The presence of the enzyme 11 beta-hydroxy-steroid dehydrogenase, which converts cortisol and corticosterone, but not aldosterone, to their 11-keto analogs, means that these analogs cannot bind to mineralocorticoid receptors.
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Outcomes after adrenalectomy for unilateral primary aldosteronism: an international consensus on outcome measures and analysis of remission rates in an international cohort
Tracy Ann Williams,Tracy Ann Williams,Jacques W.M. Lenders,Jacques W.M. Lenders,Paolo Mulatero,Jacopo Burrello,Marietta Rottenkolber,Christian Adolf,Fumitoshi Satoh,Laurence Amar,Marcus Quinkler,Jaap Deinum,Felix Beuschlein,Kanako Kiriyama Kitamoto,Uyen Thi Phuong Pham,Ryo Morimoto,Hironobu Umakoshi,Aleksander Prejbisz,Tomaz Kocjan,Mitsuhide Naruse,Michael Stowasser,Tetsuo Nishikawa,William F. Young,Celso E. Gomez-Sanchez,John W. Funder,Martin Reincke +25 more
TL;DR: Consensus was reached for criteria for six outcomes based on blood pressure, use of antihypertensive drugs, plasma potassium and aldosterone concentrations, and plasma renin concentrations or activities based on clinical and biochemical outcomes.
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Renal mineralocorticoid receptors and hippocampal corticosterone-binding species have identical intrinsic steroid specificity
TL;DR: It is suggested that hippocampal [3H]corticosterone-binding sites and renal MR may have identical intrinsic specificity for steroids, with apparent specificity differences the result of tissue-specific sequestration of naturally occurring steroids other than Aldo.
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Proopiomelanocortin Processing in the Pituitary, Central Nervous System, and Peripheral Tissues
A. Ian Smith,John W. Funder +1 more
TL;DR: To yield biologically active products, precursors commonly undergo a series of highly organized posttranslational events, including selective proteolytic cleavage and other enzymatic modifications which take place within specific membrane-bounded compartments.