J
Jon C. D. Houtman
Researcher at University of Iowa
Publications - 71
Citations - 3021
Jon C. D. Houtman is an academic researcher from University of Iowa. The author has contributed to research in topics: T-cell receptor & T cell. The author has an hindex of 27, co-authored 66 publications receiving 2644 citations. Previous affiliations of Jon C. D. Houtman include Veterans Health Administration & Mayo Clinic.
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Journal ArticleDOI
NetPath: a public resource of curated signal transduction pathways
Kumaran Kandasamy,Subburaman Mohan,Rajesh Raju,Shivakumar Keerthikumar,Ghantasala S. Sameer Kumar,Abhilash K. Venugopal,Deepthi Telikicherla,Daniel J. Navarro,Suresh Mathivanan,Christian Pecquet,Sashi Kanth Gollapudi,Sudhir Gopal Tattikota,Shyam Mohan,Hariprasad Padhukasahasram,Yashwanth Subbannayya,Renu Goel,Harrys K.C. Jacob,Jun Zhong,Raja Sekhar,Vishalakshi Nanjappa,Lavanya Balakrishnan,Roopashree Subbaiah,Y. L. Ramachandra,B. Abdul Rahiman,T. S. Keshava Prasad,Jian Xin Lin,Jon C. D. Houtman,Stephen Desiderio,Jean-Christophe Renauld,Stefan N. Constantinescu,Osamu Ohara,Toshio Hirano,Masato Kubo,S. Singh,Purvesh Khatri,Sorin Draghici,Gary D. Bader,Gary D. Bader,Chris Sander,Warren J. Leonard,Akhilesh Pandey +40 more
TL;DR: NetPath provides detailed maps of a number of immune signaling pathways, which include approximately 1,600 reactions annotated from the literature and more than 2,800 instances of transcriptionally regulated genes - all linked to over 5,500 published articles.
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Studying multisite binary and ternary protein interactions by global analysis of isothermal titration calorimetry data in SEDPHAT: Application to adaptor protein complexes in cell signaling
Jon C. D. Houtman,Patrick O. Brown,Brent Bowden,Hiroshi Yamaguchi,Ettore Appella,Lawrence E. Samelson,Peter Schuck +6 more
TL;DR: A new computational platform for the global analysis of isothermal titration calorimetry (ITC) data for the study of binary and ternary multisite interactions, implemented as part of the public domain multimethod analysis software SEDPHAT is described.
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Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1.
Jon C. D. Houtman,Hiroshi Yamaguchi,Mira Barda-Saad,Alex Braiman,Brent Bowden,Ettore Appella,Peter Schuck,Lawrence E. Samelson +7 more
TL;DR: It is observed that the simultaneous association of GRB2, via its SH2 and SH3 domains, with multivalent ligands led to the oligomerization of these ligands, which affected signaling.
Journal ArticleDOI
Early Phosphorylation Kinetics of Proteins Involved in Proximal TCR-Mediated Signaling Pathways
TL;DR: These studies indicate that linker for activation of T cells’ tyrosines have substantially different phosphorylation kinetics and that Src homology 2 domain-containing leukocyte protein of 76 kDa has rapid, transient phosphorylated kinetics compared to other proteins.
Journal ArticleDOI
Binding specificity of multiprotein signaling complexes is determined by both cooperative interactions and affinity preferences.
Jon C. D. Houtman,Yuichiro Higashimoto,Nazzareno Dimasi,Sangwoo Cho,Hiroshi Yamaguchi,Brent Bowden,Carole K. Regan,Emilio L. Malchiodi,Roy A. Mariuzza,Peter Schuck,E Appella,Lawrence E. Samelson +11 more
TL;DR: This study used multiple biochemical and biophysical methods to examine the binding properties of several SH2 and SH3 domain-containing signaling proteins as they interact with the adapter protein linker for activation of T-cells (LAT) to form multiprotein complexes.