J
Jon Kar Zubieta
Researcher at University of Utah
Publications - 228
Citations - 22617
Jon Kar Zubieta is an academic researcher from University of Utah. The author has contributed to research in topics: Endogenous opioid & Major depressive disorder. The author has an hindex of 72, co-authored 225 publications receiving 20696 citations. Previous affiliations of Jon Kar Zubieta include University of Michigan & Mental Health Research Institute.
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Journal ArticleDOI
Human brain mechanisms of pain perception and regulation in health and disease.
TL;DR: A systematic review of the literature regarding how activity in diverse brain regions creates and modulates the experience of acute and chronic pain states, emphasizing the contribution of various imaging techniques to emerging concepts is presented in this paper.
Journal ArticleDOI
COMT val158met Genotype Affects µ-Opioid Neurotransmitter Responses to a Pain Stressor
Jon Kar Zubieta,Mary M. Heitzeg,Yolanda R. Smith,Joshua A. Bueller,Ke Xu,Yanjun Xu,Robert A. Koeppe,Christian S. Stohler,David Goldman +8 more
TL;DR: Individuals homozygous for themet158 allele of the catechol-O-methyltransferase (COMT) polymorphism showed diminished regional μ-opioid system responses to pain compared with heterozygotes, and these effects were accompanied by higher sensory and affective ratings of pain and a more negative internal affective state.
Journal ArticleDOI
Regional mu opioid receptor regulation of sensory and affective dimensions of pain.
Jon Kar Zubieta,Yolanda R. Smith,Joshua A. Bueller,Yanjun Xu,Michael R. Kilbourn,Douglas M. Jewett,Charles R. Meyer,Robert A. Koeppe,Christian S. Stohler +8 more
TL;DR: Sustained pain induced the regional release of endogenous opioids interacting with μ-opioid receptors in a number of cortical and subcortical brain regions, resulting in reductions in the sensory and affective ratings of the pain experience.
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Placebo Effects Mediated by Endogenous Opioid Activity on μ-Opioid Receptors
Jon Kar Zubieta,Joshua A. Bueller,Lisa R. Jackson,D. Scott,Yanjun Xu,Robert A. Koeppe,Thomas E. Nichols,Christian S. Stohler +7 more
TL;DR: Cognitive factors (e.g., expectation of pain relief) are capable of modulating physical and emotional states through the site-specific activation of μ-opioid receptor signaling in the human brain.
Journal ArticleDOI
Neurobiological Mechanisms of the Placebo Effect
TL;DR: It is necessary to eliminate the specific action of a therapy and to simulate a context that is similar in all respects to that of a real treatment to study this psychosocial context.