Jonas Dehairs

TL;DR: In several human and mouse cancer cell lines and carcinomas, a sapienate biosynthesis pathway underpins metabolic plasticity by allowing these cells to bypass stearoyl-CoA desaturase-dependent fatty acid desaturation.

TL;DR: Pre-clinical studies illustrate the translational promise of exploiting lipid metabolism in cancer, and critically, have shown context dependent actionable vulnerabilities that can be rationally targeted, particularly in combinatorial approaches.

TL;DR: CRISP-ID is presented, a web application which uses a unique algorithm for genotyping up to three alleles from a single Sanger sequencing trace, providing a robust and readily accessible platform to directly identify indels and significantly speed up the characterization of clones.

TL;DR: Using both shotgun and 2D‐imaging lipidomics analysis, a hitherto unrecognized alteration in phospholipid profiles in NSCLC is uncovered, which may have important biological implications and may have significant potential for biomarker development.

TL;DR: To delineate the functional outcome of chromosome 8p loss of heterozygosity (LOH), a common aberration in breast cancer, this work modeled 8p LOH using TALEN-based genomic engineering and found the shift in lipid metabolism triggers invasiveness and confers tumor growth under stress conditions due to increased autophagy.