J
Jonas Frisén
Researcher at Karolinska Institutet
Publications - 196
Citations - 35321
Jonas Frisén is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Neural stem cell & Stem cell. The author has an hindex of 53, co-authored 188 publications receiving 30414 citations. Previous affiliations of Jonas Frisén include Mercer University & University of Giessen.
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Journal ArticleDOI
Evidence for cardiomyocyte renewal in humans
Olaf Bergmann,Ratan D. Bhardwaj,Samuel Bernard,Sofia Zdunek,Fanie Barnabé-Heider,Stuart Walsh,Joel Zupicich,Kanar Alkass,Bruce A. Buchholz,Henrik Druid,Stefan Jovinge,Jonas Frisén +11 more
TL;DR: The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this process in cardiac pathologies.
Journal ArticleDOI
Dynamics of fat cell turnover in humans
Kirsty L. Spalding,Erik Arner,Pål O. Westermark,Samuel Bernard,Bruce A. Buchholz,Olaf Bergmann,Lennart Blomqvist,Johan Hoffstedt,Erik Näslund,Tom Britton,Hernan Concha,Moustapha Hassan,Mikael Rydén,Jonas Frisén,Peter Arner +14 more
TL;DR: It is shown that adipocyte number is a major determinant for the fat mass in adults, however, the number of fat cells stays constant in adulthood in lean and obese individuals, even after marked weight loss, indicating that thenumber of adipocytes is set during childhood and adolescence.
Journal ArticleDOI
Identification of a Neural Stem Cell in the Adult Mammalian Central Nervous System
TL;DR: Evidence is presented that ependymal cells are neural stem cells and a novel process in the response to central nervous system injury is identified, identified in response to spinal cord injury.
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Visualization and analysis of gene expression in tissue sections by spatial transcriptomics
Patrik L. Ståhl,Patrik L. Ståhl,Fredrik Salmén,Sanja Vickovic,Anna Lundmark,Anna Lundmark,José Fernández Navarro,José Fernández Navarro,Jens P. Magnusson,Stefania Giacomello,Michaela Asp,Jakub Orzechowski Westholm,Mikael Huss,Annelie Mollbrink,Sten Linnarsson,Simone Codeluppi,Åke Borg,Fredrik Pontén,Paul I. Costea,Pelin Sahlén,Jan Mulder,Olaf Bergmann,Joakim Lundeberg,Jonas Frisén +23 more
TL;DR: By positioning histological sections on arrayed reverse transcription primers with unique positional barcodes, this work demonstrates high-quality RNA-sequencing data with maintained two-dimensional positional information from the mouse brain and human breast cancer.
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Dynamics of Hippocampal Neurogenesis in Adult Humans
Kirsty L. Spalding,Olaf Bergmann,Kanar Alkass,Samuel Bernard,Mehran Salehpour,Hagen B. Huttner,Hagen B. Huttner,Emil Boström,Isabelle Westerlund,Céline Vial,Bruce A. Buchholz,Göran Possnert,Deborah C. Mash,Henrik Druid,Jonas Frisén +14 more
TL;DR: It is concluded that neurons are generated throughout adulthood and that the rates are comparable in middle-aged humans and mice, suggesting that adult hippocampal neurogenesis may contribute to human brain function.