J
Jonas Klingström
Researcher at Karolinska Institutet
Publications - 134
Citations - 7221
Jonas Klingström is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Hantavirus & Medicine. The author has an hindex of 34, co-authored 107 publications receiving 4926 citations. Previous affiliations of Jonas Klingström include Public Health Agency of Sweden & Karolinska University Hospital.
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Journal ArticleDOI
Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19.
Takuya Sekine,André Perez-Potti,Olga Rivera-Ballesteros,Kristoffer Strålin,Jean Baptiste Gorin,Annika Olsson,Sian Llewellyn-Lacey,Habiba Kamal,Gordana Bogdanovic,Sandra Muschiol,David J. Wullimann,Tobias Kammann,Johanna Emgård,Tiphaine Parrot,Elin Folkesson,Olav Rooyackers,Lars Eriksson,Jan-Inge Henter,Anders Sönnerborg,Tobias Allander,Jan Albert,Morten Nielsen,Jonas Klingström,Sara Gredmark-Russ,Niklas K. Björkström,Johan K. Sandberg,David Price,Hans-Gustaf Ljunggren,Soo Aleman,Marcus Buggert +29 more
TL;DR: It is shown that SARS-CoV-2 elicits robust, broad and highly functional memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.
Journal ArticleDOI
Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus
Niklas K. Björkström,Therese Lindgren,Malin Stoltz,Cyril Fauriat,Cyril Fauriat,Monika Braun,Magnus Evander,Jakob Michaëlsson,Karl-Johan Malmberg,Jonas Klingström,Clas Ahlm,Hans-Gustaf Ljunggren +11 more
TL;DR: This work has shown that acute hantavirus infection in humans triggers a rapid expansion and long-term persistence of NK cells, which in turn influences the ability of these cells to reprogram and reprogram themselves for use in wound healing.
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Natural killer cell immunotypes related to COVID-19 disease severity.
Christopher Maucourant,Iva Filipovic,Andrea Ponzetta,Soo Aleman,Soo Aleman,Martin Cornillet,Laura Hertwig,Benedikt Strunz,Antonio Lentini,Björn Reinius,Demi Brownlie,Angelica Cuapio,Eivind Heggernes Ask,Eivind Heggernes Ask,Ryan M. Hull,Alvaro Haroun-Izquierdo,Marie Schaffer,Jonas Klingström,Elin Folkesson,Elin Folkesson,Marcus Buggert,Johan K. Sandberg,Lars Eriksson,Lars Eriksson,Olav Rooyackers,Olav Rooyackers,Hans-Gustaf Ljunggren,Karl-Johan Malmberg,Karl-Johan Malmberg,Karl-Johan Malmberg,Jakob Michaëlsson,Nicole Marquardt,Quirin Hammer,Kristoffer Strålin,Kristoffer Strålin,Niklas K. Björkström +35 more
TL;DR: The NK cell activation landscape in acute SARS-CoV-2 infection is associated with COVID-19 disease severity, and arming of CD56bright NK cells was observed across COIDs disease states, driven by a defined protein-protein interaction network of inflammatory soluble factors.
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Processing of genome 5' termini as a strategy of negative-strand RNA viruses to avoid RIG-I-dependent interferon induction.
Matthias Habjan,Ida Andersson,Jonas Klingström,Michael Schümann,Arnold Martin,Petra Zimmermann,Valentina Wagner,Andreas Pichlmair,Urs Schneider,Elke Mühlberger,Ali Mirazimi,Friedemann Weber +11 more
TL;DR: RIG-I is established as a major intracellular recognition receptor for the genome of most negative-strand RNA viruses and the cleavage of triphosphates at the RNA 5′ end as a strategy of viruses to evade the innate immune response is defined.
Journal ArticleDOI
Nitric Oxide Inhibits the Replication Cycle of Severe Acute Respiratory Syndrome Coronavirus
Sara Åkerström,Mehrdad Mousavi-Jazi,Jonas Klingström,Mikael Leijon,Åke Lundkvist,Ali Mirazimi +5 more
TL;DR: It is demonstrated that inducible nitric oxide synthase, an enzyme that produces NO, inhibits the SARS CoV replication cycle and that NO inhibits viral protein and RNA synthesis.