Jonas van den Brink

TL;DR: N nanoscale RyR reorganization during HF augments Ca2+ leak and slows Ca2+.

TL;DR: Novel approaches to quantitatively describe the nanoscale, 3D organization of ryanodine receptors (RyRs) in cardiomyocytes were developed and RyR clusters were found to be significantly smaller than previous 2D estimates.

TL;DR: A preferentially voltage- dependent, rather than time-dependent, effect with respect to refractoriness at physiologically relevant rates in human atria is suggested, as the resting membrane potential is hyperpolarized in chronic atrial fibrillation, the voltage-dependence of excitability dominates, profoundly increasing the risk for arrhythmia re-initiation and maintenance in fibrillating atria.

TL;DR: The present work uses the 3-D Kirchhoff-Nernst-Planck (KNP) framework to simulate the dynamics of ion concentrations and the electrical potential surrounding a morphologically detailed pyramidal cell, and elucidates the single neuron contribution to electrodiffusive effects in the ECS.