J
Jonathan Abraham
Researcher at Harvard University
Publications - 33
Citations - 3697
Jonathan Abraham is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & Antibody. The author has an hindex of 14, co-authored 23 publications receiving 2917 citations. Previous affiliations of Jonathan Abraham include National Institutes of Health & Howard Hughes Medical Institute.
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Journal ArticleDOI
HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T-cells
Michael R. Betts,Martha Nason,Sadie M. West,Stephen C. De Rosa,Stephen A. Migueles,Jonathan Abraham,Michael M. Lederman,Jose M. Benito,Paul A. Goepfert,Mark Connors,Mario Roederer,Richard A. Koup +11 more
TL;DR: The quality of the HIV-specific CD8(+) T-cell functional response serves as an immune correlate of HIV disease progression and a potential qualifying factor for evaluation of HIV vaccine efficacy.
Journal ArticleDOI
Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses
Sheli R. Radoshitzky,Jonathan Abraham,Christina F. Spiropoulou,Jens H. Kuhn,Jens H. Kuhn,Dan Nguyen,Wenhui Li,Jane Nagel,Paul J. Schmidt,Jack H. Nunberg,Nancy C. Andrews,Michael Farzan,Hyeryun Choe +12 more
TL;DR: TfR1 is a cellular receptor for New World haemorrhagic fever arenaviruses, and a specific, high-affinity association between transferrin receptor 1 (TFR1) and the entry glycoprotein (GP) of Machupo virus is shown.
FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation
Caroline Junqueira,Ângela C. Crespo,Shahin Ranjbar,Luna B de Lacerda,Mercedes Lewandrowski,Jacob Ingber,B. Parry,Sagi Ravid,Sarah Clark,Marie Rose Schrimpf,F. Ho,Caroline L. Beakes,Justin D. Margolin,Nicole M. Russell,Kyle R. Kays,Julie Boucau,Upasana Das Adhikari,Setu M. Vora,Valerie Leger,Lee Gehrke,Lauren A. Henderson,Erin Janssen,Douglas S. Kwon,Chris Sander,Jonathan Abraham,Marcia B. Goldberg,Haoying Wu,Gautam Raju Mehta,S. Bell,Anne E. Goldfeld,Michael R. Fil,Judy Lieberman +31 more
TL;DR: It is suggested that antibody-mediated SARS-CoV-2 uptake by monocytes/macrophages triggers inflammatory cell death that aborts production of infectious virus but causes systemic inflammation that contributes to COVID-19 pathogenesis.
Journal ArticleDOI
Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax
Jakub Gruszczyk,Usheer Kanjee,Li Jin Chan,Li Jin Chan,Sebastien Menant,Benoit Malleret,Benoit Malleret,Nicholas T.Y. Lim,Christoph Q. Schmidt,Yee-Foong Mok,Kai-Min Lin,Richard D. Pearson,Richard D. Pearson,Gabriel W. Rangel,Brian J. Smith,Melissa J. Call,Melissa J. Call,Michael P. Weekes,Michael D. W. Griffin,James M. Murphy,James M. Murphy,Jonathan Abraham,Kanlaya Sriprawat,Maria J. Menezes,Marcelo U. Ferreira,Bruce Russell,Laurent Rénia,Manoj T. Duraisingh,Wai-Hong Tham,Wai-Hong Tham +29 more
TL;DR: Using Brazilian and Thai clinical isolates, data show that TfR1-PvRBP2b invasion pathway is critical for the recognition of reticulocytes during P. vivax invasion.
Journal ArticleDOI
Structural basis for receptor recognition by New World hemorrhagic fever arenaviruses
Jonathan Abraham,Kevin D. Corbett,Michael Farzan,Hyeryun Choe,Stephen C. Harrison,Stephen C. Harrison +5 more
TL;DR: It is proposed that New World arenaviruses that are pathogenic to humans fortuitously acquired affinity for human TfR1 during adaptation to Tf R1 of their natural hosts.