J
Jonathan K. Stiles
Researcher at Morehouse School of Medicine
Publications - 6
Citations - 465
Jonathan K. Stiles is an academic researcher from Morehouse School of Medicine. The author has contributed to research in topics: Artemether & CXCL10. The author has an hindex of 5, co-authored 6 publications receiving 367 citations.
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Journal ArticleDOI
The emerging role of CXCL10 in cancer (Review)
TL;DR: This review focuses on current research elucidating the emerging role of CXCL10 in the pathogenesis of cancer, and examines its role as a potential biomarker and therapeutic target for related human malignancies.
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Pharmacologic Inhibition of CXCL10 in Combination with Anti-malarial Therapy Eliminates Mortality Associated with Murine Model of Cerebral Malaria
Nana O. Wilson,Wesley Solomon,Leonard M. Anderson,John Patrickson,Sidney Pitts,Vincent C. Bond,Mingli Liu,Jonathan K. Stiles +7 more
TL;DR: Results indicate that CXCL10 induces apoptosis in HBVECs and neuroglia cells in a dose-dependent manner suggesting that increased levels of CX CL10 in CM patients may play a role in vasculopathy, neuropathogenesis, and brain injury during CM pathogenesis.
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STAT3 Regulates MMP3 in Heme-Induced Endothelial Cell Apoptosis
TL;DR: This study further tested the hypothesis that Heme reduces blood-brain barrier integrity during ECM by induction of apoptosis of brain vascular endothelial cells through STAT3 and its target gene matrix metalloproteinase three (MMP3) signaling.
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Neuregulin-1 attenuates mortality associated with experimental cerebral malaria
Wesley Solomon,Nana O. Wilson,Leonard M. Anderson,Sidney Pitts,John Patrickson,Mingli Liu,Byron D. Ford,Jonathan K. Stiles +7 more
TL;DR: This study suggests that NRG-1 attenuates ECM-associated brain inflammation and injuries and may represent a novel supportive therapy for the management of CM.
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Plasma BDNF and PDGF-AA levels are associated with high TCD velocity and stroke in children with sickle cell anemia.
Hyacinth I. Hyacinth,Beatrice E. Gee,Thomas V. Adamkiewicz,Robert J. Adams,Abdullah Kutlar,Jonathan K. Stiles,Jacqueline M. Hibbert +6 more
TL;DR: A role for BDNF and PDGF-AA is suggested in the patho-physiological mechanism of cerebrovascular disease in SCA, both associated with severity of anemia and high trans-cranial Doppler velocity.