J
Jonathan P. Knowles
Researcher at Northumbria University
Publications - 27
Citations - 1100
Jonathan P. Knowles is an academic researcher from Northumbria University. The author has contributed to research in topics: Ring (chemistry) & Flow chemistry. The author has an hindex of 13, co-authored 26 publications receiving 996 citations. Previous affiliations of Jonathan P. Knowles include University of Bristol & Durham University.
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Journal ArticleDOI
Flow photochemistry: Old light through new windows
TL;DR: This review highlights the use of flow reactors in organic photochemistry, allowing a comparison of the various reactor types to be made.
Journal ArticleDOI
The Heck-Mizoroki cross-coupling reaction: a mechanistic perspective.
TL;DR: This perspective aims to review and compare works and to provide an up-to-date view of the Heck-Mizoroki cross-coupling reaction.
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Batch versus Flow Photochemistry: A Revealing Comparison of Yield and Productivity
Luke D. Elliott,Jonathan P. Knowles,Paul J. Koovits,Katie G. Maskill,Michael J. Ralph,Guillaume Lejeune,Lee Edwards,Richard I. Robinson,Ian Clemens,Brian Cox,David D. Pascoe,Guido Koch,Martin Eberle,Malcolm B. Berry,Kevin I. Booker-Milburn +14 more
TL;DR: A broad range of synthetic photochemical transformations were optimized in both reactor modes and their yields and productivities compared and it was revealed that the productivity of flow reactors varied very little to that of their batch counterparts when the key reaction parameters were matched.
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Complexity from Simplicity: Tricyclic Aziridines from the Rearrangement of Pyrroles by Batch and Flow Photochemistry
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Mechanistic studies on the Heck-Mizoroki cross-coupling reaction of a hindered vinylboronate ester as a key approach to developing a highly stereoselective synthesis of a C1-C7 Z,Z,E-triene synthon for viridenomycin.
TL;DR: Mechanistic studies of the Heck-Mizoroki reaction of a vinylboronate ester with electronically different (four-substituted) aryl iodides shows that electron donors accelerate the cross-coupling, demonstrating that the oxidative addition step is not rate determining and that there is development of some degree of positive charge in the rate determining step.