Author
Jonathan Sperry
Other affiliations: University of Exeter
Bio: Jonathan Sperry is an academic researcher from University of Auckland. The author has contributed to research in topics: Total synthesis & Indole test. The author has an hindex of 25, co-authored 160 publications receiving 2285 citations. Previous affiliations of Jonathan Sperry include University of Exeter.
Papers published on a yearly basis
Papers
More filters
TL;DR: As of early 2013, over 200 natural products are known to contain a nitrogen-nitrogen (N-N) bond and this report describes their isolation and biological activity.
Abstract: As of early 2013, over 200 natural products are known to contain a nitrogen-nitrogen (N-N) bond. This report categorizes these compounds by structural class and details their isolation and biological activity.
258 citations
TL;DR: A review of the isolation, biological activity and synthesis of natural products containing a benzannulated spiroketal moiety is provided.
129 citations
University of Newcastle1, Lancaster University2, Nanjing University of Science and Technology3, Sabaragamuwa University4, New York University5, Hong Kong Polytechnic University6, University of Wuppertal7, Korea University8, United States Environmental Protection Agency9, Luleå University of Technology10, University of Auckland11, Kansas State University12, Foshan University13, University of Hong Kong14, Tsinghua University15, Sejong University16
TL;DR: Future studies should focus on quantifying the potential leaching of the mobilized PFAS in the absence of removal by plant and biota uptake or soil washing, and regular monitoring of the long-term stability of the immobilized PFAS.
128 citations
TL;DR: In this review, the isolation of these mushroom-derived indole alkaloids is discussed, along with their associated biological activities.
Abstract: Mushrooms are known to produce over 140 natural products bearing an indole heterocycle. In this review, the isolation of these mushroom-derived indole alkaloids is discussed, along with their associated biological activities.
99 citations
TL;DR: A review of the isolation, biological activity and synthesis of pyranonaphthoquinones and closely related compounds is provided.
75 citations
Cited by
More filters
TL;DR: This review covers the literature published in 2014 for marine natural products, with 1116 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.
4,649 citations
TL;DR: An overview of Pd-catalyzed N-arylation reactions found in both basic and applied chemical research from 2008 to the present is provided.
Abstract: Pd-catalyzed cross-coupling reactions that form C–N bonds have become useful methods to synthesize anilines and aniline derivatives, an important class of compounds throughout chemical research. A key factor in the widespread adoption of these methods has been the continued development of reliable and versatile catalysts that function under operationally simple, user-friendly conditions. This review provides an overview of Pd-catalyzed N-arylation reactions found in both basic and applied chemical research from 2008 to the present. Selected examples of C–N cross-coupling reactions between nine classes of nitrogen-based coupling partners and (pseudo)aryl halides are described for the synthesis of heterocycles, medicinally relevant compounds, natural products, organic materials, and catalysts.
1,709 citations
TL;DR: Gold(I) complexes selectively activate π-bonds of alkenes in complex molecular settings, which has been attributed to relativistic effects as discussed by the authors, and are the most effective catalysts for the electrophilic activation of alkynes under homogeneous conditions.
Abstract: 1.1. General Reactivity of Alkyne-Gold(I) Complexes
For centuries, gold had been considered a precious, purely decorative inert metal. It was not until 1986 that Ito and Hayashi described the first application of gold(I) in homogeneous catalysis.1 More than one decade later, the first examples of gold(I) activation of alkynes were reported by Teles2 and Tanaka,3 revealing the potential of gold(I) in organic synthesis. Now, gold(I) complexes are the most effective catalysts for the electrophilic activation of alkynes under homogeneous conditions, and a broad range of versatile synthetic tools have been developed for the construction of carbon–carbon or carbon–heteroatom bonds.
Gold(I) complexes selectively activate π-bonds of alkynes in complex molecular settings,4−10 which has been attributed to relativistic effects.11−13 In general, no other electrophilic late transition metal shows the breadth of synthetic applications of homogeneous gold(I) catalysts, although in occasions less Lewis acidic Pt(II) or Ag(I) complexes can be used as an alternative,9,10,14,15 particularly in the context of the activation of alkenes.16,17 Highly electrophilic Ga(III)18−22 and In(III)23,24 salts can also be used as catalysts, although often higher catalyst loadings are required.
In general, the nucleophilic Markovnikov attack to η2-[AuL]+-activated alkynes 1 forms trans-alkenyl-gold complexes 2 as intermediates (Scheme 1).4,5a,9,10,12,25−29 This activation mode also occurs in gold-catalyzed cycloisomerizations of 1,n-enynes and in hydroarylation reactions, in which the alkene or the arene act as the nucleophile.
Scheme 1
Anti-Nucleophilic Attack to η2-[AuL]+-Activated Alkynes
1,260 citations
TL;DR: The present review will focus mainly on the recent literature for applications of this reaction in the field of medicinal chemistry, in particular on use of the 1,2,3-triazole moiety as pharmacophore.
Abstract: The copper(I)-catalyzed 1,2,3-triazole-forming reaction between azides and terminal alkynes has become the gold standard of 'click chemistry' due to its reliability, specificity, and biocompatibility. Applications of click chemistry are increasingly found in all aspects of drug discovery; they range from lead finding through combinatorial chemistry and target-templated in vitro chemistry, to proteomics and DNA research by using bioconjugation reactions. The triazole products are more than just passive linkers; they readily associate with biological targets, through hydrogen-bonding and dipole interactions. The present review will focus mainly on the recent literature for applications of this reaction in the field of medicinal chemistry, in particular on use of the 1,2,3-triazole moiety as pharmacophore.
983 citations