Jong Woo Lee

TL;DR: In this paper, the authors performed mutational analysis of the PIK3CA gene by polymerase chain reaction-single-strand conformation polymorphism assay in 668 cases of common human cancers, including hepatocellular carcinomas, acute leukemias, gastric carcinoma, breast carcinomas and non-small-cell lung cancers.

TL;DR: It is indicated that in addition to non–small-cell lung cancer, SCCHN harbors the EGFR gene mutations, and the rationale for the clinical applicability of gefinitib toSCCHN patients is suggested.

TL;DR: The presence of caspase-8 mutation in colon carcinomas suggests that casp enzyme-8 gene mutation might lead to the loss of its apoptotic function and contribute to the pathogenesis of colorectal carcinomas, especially at the late stage of colorean carcinogenesis.

TL;DR: This study showed that in addition to lung adenocarcinomas, ERBB2 kinase domain mutation occurs in other common human cancers such as gastric, breast, and colorectal cancers, and suggested that alterations of ER BB2-mediated signaling pathway by ERBB 2 mutations alone or together with K-RAS mutations may contribute to the development of human cancers.

TL;DR: The data indicate that beclin‐1 inactivation by loss of expression may not occur in colorectal and gastric cancers and suggests that neo‐expression of beclIn‐1 may play a role in both coloreCTal and Gastric tumorigenesis.