Author
Joon Hee Hong
Other affiliations: Harbin University of Commerce, Ewha Womans University, Korea Institute of Science and Technology
Bio: Joon Hee Hong is an academic researcher from Chosun University. The author has contributed to research in topics: Nucleoside & Phosphonate. The author has an hindex of 13, co-authored 175 publications receiving 786 citations. Previous affiliations of Joon Hee Hong include Harbin University of Commerce & Ewha Womans University.
Topics: Nucleoside, Phosphonate, Moiety, Metathesis, Ring-closing metathesis
Papers published on a yearly basis
Papers
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TL;DR: Very efficient synthetic route to novel 4′α-C -hydroxymethyl branched carbocyclic nucleosides was described in this article, which was successfully achieved by Johnson orthoester-Claisen rearrangement, ring-closing metathesis (RCM) starting from a simple acyclic precursor 1,3-dihydoxy acetone.
61 citations
TL;DR: HPLC results showed that EX624 was not only able to hydrolyze commercially available pure beechwood xylan to xylose, xylobiose and xylotriose, but also abundantly available lignocellulosic agricultural residues in nature such as wheat bran to xyooligosaccharides.
33 citations
TL;DR: An efficient synthetic route for various types of novel carbocyclic nucleosides is described with use of Grubbs cyclization and Trost allylic alkylation from the carbohydrate chiral template "D-lactose".
Abstract: This paper describes an efficient synthetic route for various types of novel carbocyclic nucleosides The required stereochemistry of the targeted nucleosides was successfully obtained with use of Grubbs cyclization and Trost allylic alkylation from the carbohydrate chiral template "D-lactose"
32 citations
TL;DR: A new series of 1β‐methylcarbapenems having spiro[2,4]heptane moieties having hydroxy a moiety showed the most potent antibacterial activity.
Abstract: The synthesis of a new series of 1beta-methylcarbapenems having spiro[2,4]heptane moieties is described. Their in-vitro antibacterial activities against both gram-positive and gram-negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. Most compounds were shown to be more active than the compared meropenem and imipenem against Escherichia coli. One particular compound, IIIb, having hydroxy a moiety showed the most potent antibacterial activity.
25 citations
TL;DR: In this article, the authors investigated the gastrointestinal stability and cellular uptake characteristics of l-valyl-ara-C, a peptidomimetic prodrug of ara-C (cytarabine).
Abstract: This study aimed to investigate the gastrointestinal stability and the cellular uptake characteristics of l-valyl-ara-C, a peptidomimetic prodrug of ara-C (cytarabine). After the synthesis of l-valyl-ara-C via the incorporation of l-valine into the N4-amino group of the cytosine ring in ara-C, the gastrointestinal stability of l-valyl-ara-C was examined using artificial gastric juice and artificial intestinal fluids. The cellular uptake characteristics of l-valyl-ara-C were also examined in Caco-2 cells. The disappearance half-life of l-valyl-ara-C was 2.2 h in artificial gastric juice, while the degradation of l-valyl-ara-C was negligible in artificial intestinal fluid and also in the supernatant above the Caco-2 cell monolayer during the 2-h incubation. The cellular accumulation of l-valyl-ara-C was 5-fold higher than that of ara-C in Caco-2 cells. Furthermore, the cellular uptake of l-valyl-ara-C did not increase proportionally to the increase in drug concentration. The cellular accumulation of l-valyl-ara-C was significantly reduced in the presence of uridine, p-aminohippurate, tetraethylammonium and small dipeptides, while it was not changed in the presence of l-valine and benzoic acid, suggesting that l-valyl-ara-C could interact with multiple uptake transporters, including peptide transporters, organic anion and cation transporters and nucleoside transporters, but might not interact with amino acid transporters. In conclusion, l-valyl-ara-C could be effective to improve the oral absorption of ara-C via the carrier-mediated transport pathway.
22 citations
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TL;DR: This review concludes that Etherification without Cyclization and N-Alkylation should be considered as separate science, and the proposed treatment of Etherification with Cyclization as a separate science should be reconsidered.
Abstract: 10. Patented Literature 2616 10.1. Esterification 2616 10.2. Ether Formation 2619 10.2.1. Etherification without Cyclization 2619 10.2.2. Etherification with Cyclization 2624 10.3. N-Alkylation 2625 10.4. Other Reactions 2627 11. Summary and Outlook 2628 12. Note Added in Proof 2628 13. Abbreviations Used in This Review 2629 14. Acknowledgments 2629 15. Supporting Information Available 2630 16. References 2630
909 citations
346 citations
TL;DR: The thought processes, advances in synthetic chemistry and lessons learned from antiviral testing that led to a few molecules being moved forward to eventual approval for human therapies, while others were discarded.
310 citations
TL;DR: In this article, the progress made in the chemistry, synthesis and biology of carbasugars until May 2004 is discussed, including the extensively studied carbapyranoses as well as the scarcely considered carbafuranoses.
Abstract: This review covers the progress made in the chemistry, synthesis and biology of carbasugars until May 2004. It includes the extensively studied carbapyranoses as well as the scarcely considered carbafuranoses. Specific topics discussed include the natural occurrence of carbasugars, biosynthesis and biological activity of carbasugars, conformational analysis of carbasugars, and the compilation of synthetic methods of carbafuranoses and carbapyranoses.
289 citations
255 citations