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Jordan Ohayon

Bio: Jordan Ohayon is an academic researcher from Institut Gustave Roussy. The author has co-authored 1 publications.

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Jean-Baptiste Delhorme1, Jean-Baptiste Delhorme2, Jordan Ohayon2, Sebastien Gouy2, Gerlinde Averous1, Catherine Genestie2, Léopold Gaichies2, Olivier Glehen, Jean-Marc Guilloit, Denis Pezet, François Quenet, Gwenael Ferron3, Cécile Brigand1, Philippe Morice2, Charles Honoré2, Julio Abba4, Karine Abboud5, Mohammad Alyami6, Catherine Arvieux4, Naoual Bakrin6, G. Balague, Vincent Barrau, Houda Ben Rejeb, J.M. Bereder, Isabelle Berton-Rigaud, Frédéric Bibeau7, Isabelle Bonnefoy6, Dominique Bouzard, I. Bricault4, S. Carrere, Cécile de Chaisemartin, Madleen Chassang, Anne Chevallier, Thomas Courvoisier, Peggy Dartigues2, Anthony Dohan, Julien Dubreuil6, Frédéric Dumont, Clarisse Eveno, Marie Faruch-Bilfeld, Juliette Fontaine6, Laure Fournier, Johan Gagnière, Delphine Geffroy, Laurent Ghouti, François-Noël Gilly6, Laurence Gladieff, Diane Goéré2, Aymeric Guibal, Frédéric Guyon, Bruno Heyd, Christine Hoeffel8, Constance Hordonneau, S. Isaac6, Peggy Jourdan-Enfer6, R. Kaci, R. Kianmanesh8, Catherine Labbé-Devilliers, Joëlle Lacroix, Bernard Lelong, Agnès Leroux-Broussier, Yoann Lherm, Rea Lo Dico, Gérard Lorimier, Caroline Malhaire9, Frédéric Marchal10, Pascale Mariani9, Emilie Mathiotte, Pierre Meeus, Eliane Mery, Simon Msika, Cédric Nadeau11, Pablo Ortega-Deballon, Guillaume Passot6, Olivier Pellet, P. Peyrat, Nicolas Pirro, Marc Pocard, Flora Poizat, Jack Porcheron, Anaïs Poulet6, Patrick Rat, Pierre Rousselot, P. Rousset6, Hélène Senellart, Martine Serrano6, Vincent Servois9, Olivia Sgabura, Andrea Skanjeti6, Magali Svrcek, Raphaël Tetreau, Emilie Thibaudeau, Yann Touchefeu, Jean-Jacques Tuech, Séverine Valmary-Degano, Delphine Vaudoyer6, Stéphane Velasco, Véronique Verriele-Beurrier, Laurent Villeneuve, Romuald Wernert, Franck Zinzindohoué 
01 May 2020-Ejso
TL;DR: Complete cytoreductive surgery is the cornerstone of the PK's management as a primary treatment and was associated with a better OS and DFS in a univariate analysis.
Abstract: Purpose Psammocarcinoma (PK) is a rare disease of unknown origin. We aimed to report the characteristics, management and survival of patients operated on for PK within the French Network for Rare Peritoneal Malignancies (RENAPE) expert centers. Patients and methods All consecutive cases of PK operated within all 26 RENAPE centers between 1997 and 2018 were retrospectively analyzed. Results Twenty-five patients were identified. The median age was 53 years [range 17–78]. None of the patients had extra peritoneal metastases at diagnosis. A median of 6 cycles of carboplatin-based systemic chemotherapy was delivered in 52% preoperatively (n = 13) and 56% postoperatively (n = 14); associated with placlitaxel for 12 patients. All patients were operated on. The median PCI was 23 [0–33]. Eighty-four percent had a complete cytoreductive surgery through digestive (n = 7), spleen (n = 3), pancreas (n = 1) resections and/or multiple peritonectomies (n = 11). Five patients (20%) had intraperitoneal chemotherapy. Morbidity (Dindo-Clavien ≥3) was 12%. No postoperative death occurred. After a median follow-up of 42 months (range [2–194]), the median overall (OS) and progression-free (DFS) survival times were respectively 128 months and 31 months. Eighteen patients recurred (72%), mainly in the peritoneum (n = 16). Four of them (22%) were reoperated. The 5 and 10-year DFS rates were both 20.3%. The 5 and 10-year OS rates were 62% and 51.7%, respectively. A complete cytoreductive surgery was associated with a better OS and DFS in a univariate analysis. Conclusion Complete cytoreductive surgery is the cornerstone of the PK's management as a primary treatment. Recurrence remains common and new adjuvant strategies seem needed.

3 citations


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TL;DR: In this article , the authors describe a cohort who received contemporary primary treatment for stage II-IV low grade serous ovarian/peritoneal cancer (LGSOC), including patient characteristics and determinants of relapse and disease-free survival.

4 citations

Journal ArticleDOI
TL;DR: A rare case of PPP in a 74-year-old female, discovered fortuitously within a laparotomy for gallbladder lithiasis, found that both ovaries were intact having a normal size and died of SARS-CoV-2 six days after surgery.
Abstract: Psammocarcinoma is an uncommon subtype of low-grade serous carcinoma. It is characterized by the presence of extensive psammoma bodies and can have either an ovarian or peritoneal origin. To our knowledge fewer than 30 cases of primary peritoneal psammocarcinoma (PPP) have been reported in the English literature. We report a rare case of PPP in a 74-year-old female, discovered fortuitously within a laparotomy for gallbladder lithiasis. At laparotomy, multiple nodular implants involving the omentum, the peritoneum and a magma of intestinal loops in the right iliac fossa were noted. A biopsy from nodules was performed. Gross examination showed multiple nodules of different sizes in the fat tissue. Pathologic examination showed massive psammoma bodies representing more than 75% of the tumor. The final diagnosis was psammocarcinoma. Our patient was referred to the gynecologic department for further investigation and to ascertain whether the tumor arose from the ovaries or peritoneum. Hysterectomy, bilateral adnexectomy and omentectomy were performed. Macroscopic examination showed that both ovaries were intact having a normal size. No invasion of ovarian stroma was shown in microscopic examination. The patient died of SARS-CoV-2 (COVID-19) six days after the surgery. PPP is a rare type of low-grade serous carcinoma. The behavior of this tumor is unclear, and the treatment is not standardized because of its rarity and lack of long-term follow-up. More cases need to be studied for better understanding and improvement of the management protocols.

2 citations