Jordon K. Wang

TL;DR: The transcriptional landscape of the four human HOX loci is characterized at five base pair resolution in 11 anatomic sites and 231 HOX ncRNAs are identified that extend known transcribed regions by more than 30 kilobases, suggesting transcription of ncRNA may demarcate chromosomal domains of gene silencing at a distance.

TL;DR: The results suggest that lincRNAs may serve as scaffolds by providing binding surfaces to assemble select histone modification enzymes, thereby specifying the pattern of histone modifications on target genes.

TL;DR: It is shown that the JmjC-domain-containing related proteins UTX and JMJD3 catalyse demethylation of H3K27me3/2, which identifies a small family of H 3K27 demethylases with important, evolutionarily conserved roles in H3k27 methylation regulation and in animal anterior–posterior development.

TL;DR: APelin could be effective in treating PAH by rescuing BMPR2 and PAEC dysfunction, and administration of apelin reversed PAH in mice with reduced production of APelin resulting from deletion of PPARγ in ECs.

TL;DR: Reciprocal epithelial-mesenchymal interactions shape site-specific development of skin, and maintenance of appropriate HOX transcriptional program in adult fibroblasts may serve as a source of positional memory to differentially pattern the epithelia during homeostasis and regeneration.