J
Jörg Weyermann
Researcher at Goethe University Frankfurt
Publications - 11
Citations - 939
Jörg Weyermann is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Protamine & Oligonucleotide. The author has an hindex of 11, co-authored 11 publications receiving 892 citations.
Papers
More filters
Journal ArticleDOI
A practical note on the use of cytotoxicity assays
TL;DR: There are major differences in the calculated EC(50)-values for the cytotoxic effect of choroquine and for sodium azide depending on the assay used and it is important to choose a suitable cytotoxicity assaydepending on the supposed cell death mechanism.
Journal ArticleDOI
Albumin-protamine-oligonucleotide nanoparticles as a new antisense delivery system. Part 1: physicochemical characterization.
TL;DR: A ternary system of albumin-protamine-oligonucleotide nanoparticles (AlPrO-NP) recently developed by Vogel et al could serve as a potential drug delivery system for antisense oligonucleotides.
Journal ArticleDOI
Albumin-protamine-oligonucleotide-nanoparticles as a new antisense delivery system. Part 2: cellular uptake and effect.
TL;DR: A 12-fold increased cellular uptake of oligonucleotides in comparison to free oligon nucleotides while 100% of the cells were transfected and the AlPrO-NPs showed very low cytotoxic side effects during a 24 h application.
Journal ArticleDOI
Immunostimulatory properties of CpG-oligonucleotides are enhanced by the use of protamine nanoparticles.
Miren Kerkmann,Dirk Lochmann,Jörg Weyermann,Anja Marschner,Hendrik Poeck,Moritz Wagner,Julia Battiany,Andreas Zimmer,Stefan Endres,Gunther Hartmann +9 more
TL;DR: It is found that the use of protamine nanoparticles significantly increased (20-fold) CpG-ODN mediated interferon (IFN)-alpha production of PDC and ODN uptake in PDC was only marginally enhanced.
Journal ArticleDOI
Recombinant virus like particles as drug delivery system.
TL;DR: The drug delivery system described here is based on a virus like particle consisting of the recombinant expressed major capsid protein of Polyomavirus, VP1, which offers a save way to obtain a highly purified, non pathogenic pharmaceutical excipient.