http://www.ijidonline.com/article/S120197122200056X/pdf

Treatment with Tocilizumab in Adult Patients with Moderate to Critical COVID‐19 Pneumonia: A Single‐Center Retrospective Study

Introduction Different factors are critical when assessing COVID-19 mortality, and can explain why severity differs so widely among populations. However, there is little information regarding prognostic factors and mortality in COVID-19 from Latin American countries. Objectives To determine prognostic factors in hospitalized COVID-19 patients and to evaluate the impact of tocilizumab use in patients with hyperinflammatory syndrome and severe disease defined by the National Early Warning Score 2 (NEWS2) with a value greater than or equal to seven points. Materials and methods This retrospective cohort study included hospitalized COVID-19 patients from May to July 2020. A multivariate logistic regression analysis was performed to determine independent factors associated with mortality. Results A total of 136 patients required hospital admission. In-hospital mortality was 39.7%. Mortality was observed to be potentiated by older age, LDH serum levels and the presence of type 2 diabetes mellitus. Lymphopenia and lower PaO2/FiO2 ratio were more common in these patients. Similarly, patients who died were classified more frequently with severe disease. The independent factors associated with in-hospital mortality were age greater than 65 years, type 2 diabetes mellitus, NEWS2 greater than or equal to seven points and LDH greater than 400U/L. The use of Tocilizumab alone was not related with decreased in-hospital mortality. Subgroup analysis performed in patients with hyperinflammation and severe disease showed similar results. Conclusions COVID-19 mortality in hospitalized patients was high and mainly related with older age, comorbidities, LDH and the severity of disease at hospital admission.

Prognostic Factors in Hospitalized COVID-19 Patients at the Start of the Pandemic in Colombia: A Retrospective Cohort Study

Cryptogenic organizing pneumonia is an inflammatory disease that involves the distal bronchioles, alveolar ducts, and peribronchial alveoli, producing a restrictive pulmonary pattern. We present the case of a 33-year-old man with a background of delayed psychomotor development who presented to the emergency department with a clinical picture suggesting lower respiratory infection. The patient was hospitalized and received antibiotics, without clinical improvement. Tomographic findings and poor response to treatment were taken into consideration for performing bronchoscopy with bronchoalveolar lavage and transbronchial biopsy, whose report was conclusive for cryptogenic organizing pneumonia. This clinical case shows a patient with a histopathologically confirmed diagnosis and its possible etiological association.

/pdf/neumonia-organizativa-criptogenica-4369ny7xe5.pdf

Jorge Luis Quintero Barrios

Papers

Prognostic Factors in Hospitalized COVID-19 Patients at the Start of the Pandemic in Colombia: A Retrospective Cohort Study

Neumonía organizativa criptogénica