Jorge Regueiro

Bio: Jorge Regueiro is an academic researcher from University of Vigo. The author has contributed to research in topics: Mass spectrometry & Gas chromatography. The author has an hindex of 30, co-authored 53 publications receiving 3129 citations. Previous affiliations of Jorge Regueiro include University of Santiago de Compostela & Xunta de Galicia.

Chemistry and Biological Activities of Flavonoids: An Overview

Abstract: There has been increasing interest in the research on flavonoids from plant sources because of their versatile health benefits reported in various epidemiological studies. Since flavonoids are directly associated with human dietary ingredients and health, there is need to evaluate structure and function relationship. The bioavailability, metabolism, and biological activity of flavonoids depend upon the configuration, total number of hydroxyl groups, and substitution of functional groups about their nuclear structure. Fruits and vegetables are the main dietary sources of flavonoids for humans, along with tea and wine. Most recent researches have focused on the health aspects of flavonoids for humans. Many flavonoids are shown to have antioxidative activity, free radical scavenging capacity, coronary heart disease prevention, hepatoprotective, anti-inflammatory, and anticancer activities, while some flavonoids exhibit potential antiviral activities. In plant systems, flavonoids help in combating oxidative stress and act as growth regulators. For pharmaceutical purposes cost-effective bulk production of different types of flavonoids has been made possible with the help of microbial biotechnology. This review highlights the structural features of flavonoids, their beneficial roles in human health, and significance in plants as well as their microbial production.

Formaldehyde in the Indoor Environment

Abstract: 1.1. History Formaldehyde was described in the year 1855 by the Russian scientist Alexander Michailowitsch Butlerow. The technical synthesis by dehydration of methanol was achieved in 1867 by the German chemist August Wilhelm von Hofmann. The versatility that makes it suitable for use in various industrial applications was soon discovered, and the compound was one of the first to be indexed by Chemical Abstracts Service (CAS). In 1944, Walker published the first edition of his classic work Formaldehyde.(1) Between 1900 and 1930, formaldehyde-based resins became important adhesives for wood and wood composites. The first commercial particle board was produced during World War II in Bremen, Germany. Since 1950, particle board has become an attractive alternative to solid wood for the manufacturing of furniture. Particle board and other wood-based panels were subsequently also used for the construction of housing. Adverse health effects from exposure to formaldehyde in prefabricated houses, especially irritation of the eyes and upper airways, were first reported in the mid-1960s. Formaldehyde emissions from particle boards bonded with urea formaldehyde resin were soon identified as the cause of the complaints. As a consequence, a guideline value of 0.1 ppm was proposed in 1977 by the former German Federal Agency of Health to limit human exposure in dwellings. Criteria for the limitation and regulation of formaldehyde emissions from wood-based materials were established in 1981 in Germany and Denmark. The first regulations followed in the United States in 1985 or thereabouts. In Germany and the United States, large-scale test chambers were used for the evaluation of emissions. Although the chamber method is very reliable, it is also time-consuming and expensive. This meant there was a strong demand for simple laboratory test methods.(2)