J
Jorge Sepulcre
Researcher at Harvard University
Publications - 158
Citations - 21417
Jorge Sepulcre is an academic researcher from Harvard University. The author has contributed to research in topics: Default mode network & Human brain. The author has an hindex of 47, co-authored 143 publications receiving 17780 citations. Previous affiliations of Jorge Sepulcre include University College London & Chartered Institute of Management Accountants.
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Journal ArticleDOI
The organization of the human cerebral cortex estimated by intrinsic functional connectivity
B.T. Thomas Yeo,Fenna M. Krienen,Jorge Sepulcre,Jorge Sepulcre,Mert R. Sabuncu,Mert R. Sabuncu,Danial Lashkari,Marisa O. Hollinshead,Marisa O. Hollinshead,Joshua L. Roffman,Jordan W. Smoller,Lilla Zöllei,Jonathan R. Polimeni,Bruce Fischl,Bruce Fischl,Hesheng Liu,Randy L. Buckner +16 more
TL;DR: In this paper, the organization of networks in the human cerebrum was explored using resting-state functional connectivity MRI data from 1,000 subjects and a clustering approach was employed to identify and replicate networks of functionally coupled regions across the cerebral cortex.
Journal ArticleDOI
Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer's Disease
Randy L. Buckner,Jorge Sepulcre,Tanveer Talukdar,Fenna M. Krienen,Hesheng Liu,Trey Hedden,Jessica R. Andrews-Hanna,Reisa A. Sperling,Keith A. Johnson +8 more
TL;DR: To identify regions of high connectivity in the human cerebral cortex, a computationally efficient approach was applied to map the degree of intrinsic functional connectivity across the brain and explored whether the topography of hubs could explain the pattern of vulnerability in Alzheimer's disease (AD).
Journal ArticleDOI
Functional-Anatomic Fractionation of the Brain's Default Network
Jessica R. Andrews-Hanna,Jay S. Reidler,Jorge Sepulcre,Jorge Sepulcre,Renee Poulin,Randy L. Buckner +5 more
TL;DR: The anatomy and function of the default network is explored across three studies to resolve divergent hypotheses about its contributions to spontaneous cognition and active forms of decision making.
Journal ArticleDOI
Individual Variability in Functional Connectivity Architecture of the Human Brain
Sophia Mueller,Sophia Mueller,Danhong Wang,Michael D. Fox,B.T. Thomas Yeo,B.T. Thomas Yeo,Jorge Sepulcre,Mert R. Sabuncu,Rebecca Shafee,Jie Lu,Hesheng Liu +10 more
TL;DR: Using repeated-measurement resting-state functional MRI to explore intersubject variability in connectivity revealed that regions predicting individual differences in cognitive domains are predominantly located in regions of high connectivity variability.
Journal ArticleDOI
Tau positron emission tomographic imaging in aging and early Alzheimer disease
Keith A. Johnson,Aaron P. Schultz,Rebecca A. Betensky,J. Alex Becker,Jorge Sepulcre,Dorene M. Rentz,Dorene M. Rentz,Elizabeth C. Mormino,Jasmeer P. Chhatwal,Jasmeer P. Chhatwal,Rebecca E. Amariglio,Rebecca E. Amariglio,Kate V. Papp,Kate V. Papp,Gad A. Marshall,Gad A. Marshall,Mark W. Albers,Samantha Mauro,Lesley C. Pepin,Jonathan Alverio,Kelly Judge,Marlie Philiossaint,Timothy M. Shoup,Daniel Yokell,Bradford C. Dickerson,Teresa Gomez-Isla,Bradley T. Hyman,Neil Vasdev,Reisa A. Sperling +28 more
TL;DR: Detection of focal brain tau deposition during life could greatly facilitate accurate diagnosis of Alzheimer disease (AD), staging and monitoring of disease progression, and development of disease‐modifying therapies.