J
Jørgen Kjems
Researcher at Aarhus University
Publications - 463
Citations - 36822
Jørgen Kjems is an academic researcher from Aarhus University. The author has contributed to research in topics: RNA & RNA splicing. The author has an hindex of 80, co-authored 435 publications receiving 30278 citations. Previous affiliations of Jørgen Kjems include University of Southern Denmark & Max Planck Society.
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Journal ArticleDOI
Natural RNA circles function as efficient microRNA sponges
Thomas B. Hansen,Trine I. Jensen,Bettina Hjelm Clausen,Jesper B. Bramsen,Bente Finsen,Christian Kroun Damgaard,Jørgen Kjems +6 more
TL;DR: This study serves as the first functional analysis of a naturally expressed circular RNA, ciRS-7, which contains more than 70 selectively conserved miRNA target sites, and is highly and widely associated with Argonaute proteins in a miR-7-dependent manner.
Journal ArticleDOI
The biogenesis, biology and characterization of circular RNAs.
Lasse Sommer Kristensen,Maria S. Andersen,Lotte V. W. Stagsted,Karoline K. Ebbesen,Thomas B. Hansen,Jørgen Kjems +5 more
TL;DR: Advances in high-throughput RNA sequencing and circRNA-specific computational tools have driven the development of state-of-the-art approaches for their identification, and novel approaches to functional characterization are emerging.
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Self-assembly of a nanoscale DNA box with a controllable lid.
Ebbe Sloth Andersen,Mingdong Dong,Morten Muhlig Nielsen,Kasper Jahn,Ramesh Subramani,Wael Mamdouh,Monika M. Golas,Bjoern Sander,Holger Stark,Cristiano L. P. Oliveira,Jan Skov Pedersen,Victoria Birkedal,Flemming Besenbacher,Kurt V. Gothelf,Kurt V. Gothelf,Jørgen Kjems +15 more
TL;DR: The DNA origami method is extended into three dimensions by creating an addressable DNA box that can be opened in the presence of externally supplied DNA ‘keys’, and controlled access to the interior compartment of this DNA nanocontainer could yield several interesting applications.
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Circular RNAs in cancer: opportunities and challenges in the field.
TL;DR: The current knowledge on circRNAs is reviewed in relation to their implications in tumorigenesis as well as their potential as diagnostic and prognostic biomarkers and as possible therapeutic targets in future personalized medicine.
Journal ArticleDOI
Circular RNA and miR-7 in Cancer
TL;DR: The current knowledge about the ciRS-7/miR-7 axis in cancer-related pathways is reviewed and possible models explaining the relevance of coexpressing miR- 7 along with a circRNA inhibitor are discussed.