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Jos J. Rozema

Bio: Jos J. Rozema is an academic researcher from University of Antwerp. The author has contributed to research in topics: Scheimpflug principle & Keratoconus. The author has an hindex of 24, co-authored 116 publications receiving 2215 citations. Previous affiliations of Jos J. Rozema include University of Zaragoza & Spanish National Research Council.


Papers
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Journal ArticleDOI
TL;DR: There were errors in Affiliation 1 which was incorrectly listed as ‘Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China’.
Abstract: Scientific Reports 6: Article number: 20243; published online: 01 February 2016; updated: 10 June 2016. In the original version of this Article, there were errors in Affiliation 1 which was incorrectly listed as ‘Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

320 citations

Journal ArticleDOI
TL;DR: In this paper, the authors describe the normative data for corneal Scheimpflug densitometry based on a cohort of normal participants and provide normative data that may be used as a reference facilitating research and complementing clinical examination.
Abstract: PURPOSE: To describe the normative data for corneal Scheimpflug densitometry based on a cohort of normal participants. METHODS: A total of 445 healthy participants were recruited for assessment (794 eyes). Left and right eyes were considered separately. All participants were assessed using the corneal densitometry analysis add-on to the standard software of the Oculus Pentacam. Densitometry measurements were obtained and expressed in standardized grayscale units (GSU). RESULTS: All participants were Caucasian; 42% were male and 58% were female. The mean age was 48.0 ± 15.3 years (range, 20.2-84.2 years). Mean corneal densitometry over the 12-mm-diameter area was 19.74 ± 3.89 GSU. When divided by radial zone, densitometry values were lowest in the central zone (16.76 ± 1.87 GSU) and highest in the periphery (27.36 ± 7.47 GSU). There was no difference between central zone and the surrounding 2- to 6-mm annulus (P > 0.05), though the 6- to 10-mm and the 10- to 12-mm zones displayed higher densitometry values (P < 0.001). When divided by depth, the anterior layer displayed the highest densitometry reading of 25.81 ± 5.14 GSU, which was significantly higher than that of both the central (P < 0.001) and the posterior layers (P < 0.001). Changes in corneal densitometry were correlated with age, though not within the central 6-mm-diameter ring. No sex difference was seen within the cohort. CONCLUSIONS: This add-on to the standard imaging software allows rapid and objective assessment of the corneal densitometry. We provide normative data that may be used as a reference facilitating research and complementing clinical examination.

188 citations

Journal ArticleDOI
TL;DR: The first systematic review and meta-analysis of keratoconus natural history data is reported, including 11 529 eyes, and it is reported that younger patients and those with Kmax steeper than 55 D at presentation have a significantly greater risk of progression of ker atoconus.

142 citations

Journal ArticleDOI
TL;DR: Evaluated transepithelial CXL using proparacaine drops 0.5% preserved with BAC 0.005% was less effective than standard CXL in stabilizing progressive keratoconus and only corrected distance visual acuity showed a statistically significant improvement at 6 months and 12 months.
Abstract: Purpose To evaluate the effect of benzalkonium chloride–assisted (BAC) transepithelial collagen crosslinking (CXL) in eyes with progressive keratoconus and a minimum follow-up of 6 months. Setting Department of Ophthalmology, Antwerp University Hospital, Antwerp, Belgium. Design Cohort study. Methods Eyes with progressive keratoconus had CXL treatment without epithelial debridement. The standard CXL irradiation was preceded by instillation of proparacaine drops 0.5% preserved with BAC 0.005% every 5 minutes for 30 minutes. Selected parameters of refraction assessed by Placido disk (Eyesys) and Scheimpflug (Pentacam) examinations were compared before CXL and after CXL at 6, 12, and 18 months. Results The study enrolled 53 eyes of 38 patients. Sphere, cylinder, as well as maximum keratometry (K max) simulated K values (steep, flat, astigmatism), and refractive power values (steep, flat, astigmatism) measured using the Placido disk device remained stable over the 18-month follow-up. Only corrected distance visual acuity showed a statistically significant improvement at 6 months and 12 months. The Scheimpflug device measurements of maximum K and pachymetry at the thinnest point showed statistically significant progression throughout the study. No patient developed corneal haze or other complications. Conclusion Transepithelial CXL using proparacaine drops 0.5% preserved with BAC 0.005% was less effective than standard CXL in stabilizing progressive keratoconus. Financial Disclosure No author has a financial or proprietary interest in any material or method mentioned.

129 citations

Journal ArticleDOI
TL;DR: Although this technique did not improveVisual function, restoring a functional epithelial cell layer and reducing corneal neovascularization provides an improved platform for a penetrating keratoplasty to ultimately improve visual function.
Abstract: Background To determine if a standardized, non-xenogenic, reduced manipulation cultivation and surgical transplantation of limbal stem cell grafts is a safe and effective treatment option for patients with total and partial limbal stem cell deficiency.

100 citations


Cited by
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01 Jan 1990
TL;DR: An overview of the self-organizing map algorithm, on which the papers in this issue are based, is presented in this article, where the authors present an overview of their work.
Abstract: An overview of the self-organizing map algorithm, on which the papers in this issue are based, is presented in this article.

2,933 citations

Journal Article
TL;DR: In this article, optical coherence tomography is used for high-resolution, noninvasive imaging of the human retina, including the macula and optic nerve head in normal human subjects.
Abstract: Objective: To demonstrate optical coherence tomography for high-resolution, noninvasive imaging of the human retina. Optical coherence tomography is a new imaging technique analogous to ultrasound B scan that can provide cross-sectional images of the retina with micrometer-scale resolution. Design: Survey optical coherence tomographic examination of the retina, including the macula and optic nerve head in normal human subjects. Settings Research laboratory. Participants: Convenience sample of normal human subjects. Main Outcome Measures: Correlation of optical coherence retinal tomographs with known normal retinal anatomy. Results: Optical coherence tomographs can discriminate the cross-sectional morphologic features of the fovea and optic disc, the layered structure of the retina, and normal anatomic variations in retinal and retinal nerve fiber layer thicknesses with 10- μm depth resolution. Conclusion: Optical coherence tomography is a potentially useful technique for high depth resolution, cross-sectional examination of the fundus.

1,409 citations

Journal ArticleDOI
TL;DR: Clinical investigations using stem cell products in regenerative medicine are addressing a wide spectrum of conditions using a variety of stem cell types and applications are progressing in trials, some with early benefits to patients.

1,040 citations

Patent
24 Jun 2008
TL;DR: In this paper, a point source produced on the retina of a living eye by a laser beam is reflected from the retina and received at a lenslet array of a Hartmann-Shack wavefront sensor such that each of the lenslets in the lenslet arrays forms an aerial image of the retinal point source on a CCD camera located adjacent to the array.
Abstract: A method of and apparatus for improving vision and the resolution of retinal images is described in which a point source produced on the retina of a living eye by a laser beam is reflected from the retina and received at a lenslet array of a Hartmann-Shack wavefront sensor such that each of the lenslets in the lenslet array forms an aerial image of the retinal point source on a CCD camera located adjacent to the lenslet array. The output signal from the CCD camera is acquired by a computer which processes the signal and produces a correction signal which may be used to control a compensating optical or wavefront compensation device such as a deformable mirror. It may also be used to fabricate a contact lens or intraocular lens, or to guide a surgical procedure to correct the aberrations of the eye. Any of these methods could correct aberrations beyond defocus and astigmatism, allowing improved vision and improved imaging of the inside of the eye.

523 citations