J
José J. Fuster
Researcher at Centro Nacional de Investigaciones Cardiovasculares
Publications - 67
Citations - 4235
José J. Fuster is an academic researcher from Centro Nacional de Investigaciones Cardiovasculares. The author has contributed to research in topics: Medicine & Haematopoiesis. The author has an hindex of 24, co-authored 52 publications receiving 2976 citations. Previous affiliations of José J. Fuster include University of Salamanca & Cardiovascular Institute of the South.
Papers
More filters
Journal ArticleDOI
Clonal hematopoiesis associated with Tet2 deficiency accelerates atherosclerosis development in mice
José J. Fuster,Susan MacLauchlan,María A. Zuriaga,Maya N. Polackal,Allison C. Ostriker,Raja Chakraborty,Chia-Ling Wu,Soichi Sano,Sujatha Muralidharan,Cristina Rius,Jacqueline T Vuong,Sophia Jacob,Varsha Muralidhar,Avril A. B. Robertson,Mark E. Cooper,Vicente Andrés,Karen K. Hirschi,Kathleen A. Martin,Kenneth Walsh +18 more
TL;DR: The effects of the expansion of Tet2-mutant cells in atherosclerosis-prone, low-density lipoprotein receptor–deficient mice are studied and it is found that partial bone marrow reconstitution with TET2-deficient cells was sufficient for their clonal expansion and led to a marked increase in Atherosclerotic plaque size.
Journal ArticleDOI
Adipokines: a link between obesity and cardiovascular disease.
TL;DR: The adipose tissue microenvironment and the role of adipokines in modulating systemic inflammatory responses that contribute to cardiovascular disease are focused on.
Journal ArticleDOI
Obesity-Induced Changes in Adipose Tissue Microenvironment and Their Impact on Cardiovascular Disease
TL;DR: This review focuses on the microenvironment of adipose tissue and how it influences cardiovascular disorders, including atherosclerosis and ischemic heart diseases, through the systemic actions of adipokines.
Journal ArticleDOI
Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome.
Soichi Sano,Kosei Oshima,Ying Wang,Susan MacLauchlan,Yasufumi Katanasaka,Miho Sano,María A. Zuriaga,Minoru Yoshiyama,David A. Goukassian,Mark E. Cooper,José J. Fuster,Kenneth Walsh,Kenneth Walsh +12 more
TL;DR: Tet2 deficiency in hematopoietic cells is associated with greater cardiac dysfunction in murine models of heart failure as a result of elevated IL-1β signaling, and data suggest that individuals with TET2-mediated clonal hematoiesis may be at greater risk of developing heart failure and respond better to IL- 1β-NLRP3 inflammasome inhibition.
Journal ArticleDOI
Telomere Biology and Cardiovascular Disease
José J. Fuster,Vicente Andrés +1 more
TL;DR: Experimental and human studies that have linked telomeres and associated proteins to several factors which influence cardiovascular risk, as well as to neovascularization and the pathogenesis of atherosclerosis and heart disease are discussed.