J
José Manuel García-Verdugo
Researcher at University of Valencia
Publications - 299
Citations - 44671
José Manuel García-Verdugo is an academic researcher from University of Valencia. The author has contributed to research in topics: Neurogenesis & Neural stem cell. The author has an hindex of 84, co-authored 281 publications receiving 41309 citations. Previous affiliations of José Manuel García-Verdugo include University of Southampton & Rockefeller University.
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Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain
Fiona Doetsch,Isabelle Caillé,Daniel A. Lim,José Manuel García-Verdugo,Arturo Alvarez-Buylla +4 more
TL;DR: It is shown that SVZ astrocytes act as neural stem cells in both the normal and regenerating brain and give rise to cells that grow into multipotent neurospheres in vitro.
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Cellular Composition and Three-Dimensional Organization of the Subventricular Germinal Zone in the Adult Mammalian Brain
TL;DR: The results suggest that chains of migrating neuroblasts in the SVZ may be derived from Type C cells, which had immature ultrastructural characteristics and were nestin-positive but negative to the other markers.
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Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes
Manuel Álvarez-Dolado,Ricardo Pardal,José Manuel García-Verdugo,John R. Fike,Hyun O. Lee,Klaus Pfeffer,Carlos Lois,Sean J. Morrison,Arturo Alvarez-Buylla +8 more
TL;DR: Using a simple method based on Cre/lox recombination to detect cell fusion events, it is demonstrated that bone-marrow-derived cells (BMDCs) fuse spontaneously with neural progenitors in vitro, raising the possibility that cell fusion may contribute to the development or maintenance of these key cell types.
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Astrocytes Give Rise to New Neurons in the Adult Mammalian Hippocampus
TL;DR: It is shown that SGL cells, which express glial fibrillary acidic protein and have the characteristics of astrocytes, divide and generate new neurons under normal conditions or after the chemical removal of actively dividing cells.
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Neurogenesis in adult subventricular zone.
TL;DR: This work has identified adult brain regions harboring neural stem cells and their continual generation of new neurons throughout life, an important departure from traditional views of the germinal potential of the postnatal brain.