J
José Manuel González-Sancho
Researcher at Spanish National Research Council
Publications - 43
Citations - 3985
José Manuel González-Sancho is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Wnt signaling pathway & Calcitriol receptor. The author has an hindex of 28, co-authored 41 publications receiving 3727 citations. Previous affiliations of José Manuel González-Sancho include Cornell University & Carlos III Health Institute.
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Journal ArticleDOI
Vitamin D3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of β-catenin signaling
Hector G. Palmer,José Manuel González-Sancho,Jesús Espada,Maria T. Berciano,Isabel Puig,Josep Baulida,Miguel Quintanilla,Amparo Cano,Antonio García de Herreros,Miguel Lafarga,Alberto Muñoz +10 more
TL;DR: 1α,25(OH)2D3 induces E-cadherin and modulates β-catenin–TCF-4 target genes in a manner opposite to that of β- catenin, promoting the differentiation of colon carcinoma cells.
Journal ArticleDOI
The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer
José Manuel González-Sancho,Oscar Aguilera,José Miguel García,Natalia Pendás-Franco,Cristina Peña,Santiago Cal,Antonio García de Herreros,Félix Bonilla,Alberto Muñoz +8 more
TL;DR: The data indicate that the Wnt/β-catenin pathway is downregulated by the induction of DKK-1 expression, a mechanism that is lost in colon cancer.
Journal ArticleDOI
Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer
Oscar Aguilera,Mario F. Fraga,Esteban Ballestar,Maria F. Paz,Michel Herranz,Jesús Espada,José Miguel García,Alberto Muñoz,Manel Esteller,José Manuel González-Sancho +9 more
TL;DR: It is shown for the first time that another extracellular Wnt inhibitor, the DICKKOPF-1 (DKK-1) gene, is transcriptionally silenced by CpG island promoter hypermethylation in colon cancer cell lines, whereas treatment with the DNA-demethylating agent 5-aza-2-deoxycytidine restored DKK- 1 expression.
Journal ArticleDOI
Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway
TL;DR: Evidence is presented that hormone-activated nuclear receptors prevent c-Jun phosphorylation on Ser-63/73 and, consequently, AP-1 activation, by blocking the induction of the JNK signaling cascade.
Journal ArticleDOI
The Wnt antagonist DICKKOPF-1 gene is induced by 1alpha,25-dihydroxyvitamin D3 associated to the differentiation of human colon cancer cells
Oscar Aguilera,Cristina Peña,José Miguel García,María Jesús Larriba,Paloma Ordóñez-Morán,Diego Navarro,Antonio Barbáchano,Isabel López de Silanes,Esteban Ballestar,Mario F. Fraga,Manel Esteller,Carlos Gamallo,Félix Bonilla,José Manuel González-Sancho,Alberto Muñoz +14 more
TL;DR: DKK-1 gene induction constitutes a novel mechanism of inhibition of Wnt signalling and antitumour action by 1,25(OH)2D3, and this effect is dose dependent, slow and depends on the presence of a transcription-competent nuclear vitamin D receptor (VDR).