Author
José Manuel Sousa Lobo
Bio: José Manuel Sousa Lobo is an academic researcher from University of Porto. The author has contributed to research in topics: Solid lipid nanoparticle & Medicine. The author has an hindex of 22, co-authored 67 publications receiving 6010 citations.
Papers published on a yearly basis
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TL;DR: Drug dissolution from solid dosage forms has been described by kinetic models in which the dissolved amount of drug (Q) is a function of the test time, t or Q=f(t).
4,794 citations
TL;DR: The present review is an attempt to contemplate the studied nanocarriers in the field of anticancer drugs delivery, their advantages and disadvantages and future perspectives.
213 citations
TL;DR: Natural ingredients have been used for centuries for skin care purposes and are becoming more prevalent in formulations, due to consumers’ concerns about synthetic ingredients/chemical substances.
Abstract: Natural ingredients have been used for centuries for skin care purposes. Nowadays, they are becoming more prevalent in formulations, due to consumers’ concerns about synthetic ingredients/chemical substances. The main benefits reported for plant extracts, used in skin care, include antioxidant and antimicrobial activities and tyrosinase inhibition effect. In this review, some examples of plants from Portuguese flora, whose extracts have shown good properties for skin care are presented. However, despite the known properties of plant extracts, few studies reported the development of formulations with them. More work in this field can be accomplished to meet consumer demand.
182 citations
TL;DR: The recent use of biodegradable and biocompatible polymers in colloidal carrier systems has proved to be the most effective strategy, resulting in the exponential increase of the bioavailability of the ophthalmic drugs.
181 citations
TL;DR: A maioria dos sistemas de liberacao oral de farmacos and baseada em matrizes hidrofilicas tornaram-se muito populares na formulacao de formas farmaceuticas de Liberacao modificada as discussed by the authors.
Abstract: Os sistemas de liberacao de farmacos sao parte integrante da investigacao farmaceutica. A maioria dos sistemas de liberacao oral de farmacos e baseada em matrizes polimericas. Nas duas decadas passadas, as matrizes hidrofilicas tornaram-se muito populares na formulacao de formas farmaceuticas de liberacao modificada. A escolha do polimero hidrofilico na formulacao da matriz pode fornecer uma combinacao apropriada dos mecanismos de intumescimento, de dissolucao ou de erosao e determinam a cinetica de liberacao in vitro. As matrizes de intumescimento sao sistemas monoliticos preparados pela compressao de mistura de um polimero hidrofilico e de um farmaco. Elas representam sistemas da liberacao em que os varios mecanismos podem ser adaptados ao programa de liberacao. O sucesso desses sistemas esta relacionado com a tecnologia de fabricacao e com as caracteristicas fisicas e fisico-quimicas do polimero, responsaveis pelo mecanismo de liberacao.
130 citations
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1,774 citations
TL;DR: In each case, the very slow and complete delivery of Ibuprofen was achieved under physiological conditions after 3 weeks with a predictable zero-order kinetics, which highlights the unique properties of flexible hybrid solids for adapting their pore opening to optimize the drug-matrix interactions.
Abstract: Flexible nanoporous chromium or iron terephtalates (BDC) MIL-53(Cr, Fe) or M(OH)[BDC] have been used as matrices for the adsorption and in vitro drug delivery of Ibuprofen (or alpha- p-isobutylphenylpropionic acid). Both MIL-53(Cr) and MIL-53(Fe) solids adsorb around 20 wt % of Ibuprofen (Ibuprofen/dehydrated MIL-53 molar ratio = 0.22(1)), indicating that the amount of inserted drug does not depend on the metal (Cr, Fe) constitutive of the hybrid framework. Structural and spectroscopic characterizations are provided for the solid filled with Ibuprofen. In each case, the very slow and complete delivery of Ibuprofen was achieved under physiological conditions after 3 weeks with a predictable zero-order kinetics, which highlights the unique properties of flexible hybrid solids for adapting their pore opening to optimize the drug-matrix interactions.
1,514 citations
TL;DR: The development of a software program, called DDSolver, for facilitating the assessment of similarity between drug dissolution data and to establish a model library for fitting dissolution data using a nonlinear optimization method is described.
Abstract: In recent years, several mathematical models have been developed for analysis of drug dissolution data, and many different mathematical approaches have been proposed to assess the similarity between two drug dissolution profiles. However, until now, no computer program has been reported for simplifying the calculations involved in the modeling and comparison of dissolution profiles. The purposes of this article are: (1) to describe the development of a software program, called DDSolver, for facilitating the assessment of similarity between drug dissolution data; (2) to establish a model library for fitting dissolution data using a nonlinear optimization method; and (3) to provide a brief review of available approaches for comparing drug dissolution profiles. DDSolver is a freely available program which is capable of performing most existing techniques for comparing drug release data, including exploratory data analysis, univariate ANOVA, ratio test procedures, the difference factor f
1, the similarity factor f
2, the Rescigno indices, the 90% confidence interval (CI) of difference method, the multivariate statistical distance method, the model-dependent method, the bootstrap f
2 method, and Chow and Ki’s time series method. Sample runs of the program demonstrated that the results were satisfactory, and DDSolver could be served as a useful tool for dissolution data analysis.
1,045 citations
TL;DR: A review of solid particle technologies available for improving solubility, dissolution, and bioavailability of drugs with poor aqueous solubilities is presented in this article, where the authors highlight the solid particle technology available to improve the bioavailability.
773 citations
TL;DR: The entire drug release kinetics of various published data and experimental data from commercial or prepared controlled release formulations of diltiazem and diclofenac are analyzed using the Weibull function to determine the mechanism of transport of a drug through the polymer matrix.
608 citations