J
José Marcelo Farfel
Researcher at Rush University Medical Center
Publications - 83
Citations - 4336
José Marcelo Farfel is an academic researcher from Rush University Medical Center. The author has contributed to research in topics: Dementia & Clinical Dementia Rating. The author has an hindex of 26, co-authored 79 publications receiving 3535 citations. Previous affiliations of José Marcelo Farfel include University of São Paulo & University of Western Ontario.
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Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled‐up primate brain
Frederico A. C. Azevedo,Ludmila R.B. Carvalho,Lea T. Grinberg,José Marcelo Farfel,Renata E.L. Ferretti,Renata Elaine Paraizo Leite,Wilson Jacob Filho,Roberto Lent,Suzana Herculano-Houzel +8 more
TL;DR: The findings challenge the common view that humans stand out from other primates in their brain composition and indicate that, with regard to numbers of neuronal and nonneuronal cells, the human brain is an isometrically scaled‐up primate brain.
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The dorsal raphe nucleus shows phospho-tau neurofibrillary changes before the transentorhinal region in Alzheimer's disease. A precocious onset?
Lea T. Grinberg,Udo Rüb,Renata E.L. Ferretti,Ricardo Nitrini,José Marcelo Farfel,Livia Polichiso,K. Gierga,W. Jacob-Filho,Helmut Heinsen +8 more
TL;DR: These observations support the hypothesis of transneuronal spread of neurofibrillary changes from the DR to its interconnected cortical brain areas and indicate that the supratrochlear subnucleus of the DR is affected by neurofibillary changes before the transentorhinal cortex during the disease process underlying AD.
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Sex differences in Alzheimer’s disease and common neuropathologies of aging
Shahram Oveisgharan,Zoe Arvanitakis,Lei Yu,José Marcelo Farfel,José Marcelo Farfel,Julie A. Schneider,David A. Bennett +6 more
TL;DR: Postmortem data from 1453 persons who participated in one of two longitudinal community-based studies of older adults help elucidate the neuropathologic footprint of sex difference in AD and other common brain pathologies of aging.
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Very low levels of education and cognitive reserve: A clinicopathologic study
José Marcelo Farfel,Ricardo Nitrini,Claudia K. Suemoto,Lea T. Grinberg,Renata E.L. Ferretti,Renata Elaine Paraizo Leite,Edilaine Tampellini,Luzia Carreira Lima,Daniela Souza Farias,Ricardo Caires Neves,Roberta Diehl Rodriguez,Paulo Rossi Menezes,Felipe Fregni,David A. Bennett,Carlos Augusto Pasqualucci,Wilson Jacob Filho +15 more
TL;DR: Even a few years of formal education contributes to cognitive reserve, as measured by CDR sum of boxes, and education modified the relationship of lacunar infarcts with cognitive abilities.
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Brain bank of the Brazilian aging brain study group - a milestone reached and more than 1,600 collected brains.
Lea T. Grinberg,Renata E.L. Ferretti,José Marcelo Farfel,Renata Elaine Paraizo Leite,Carlos Augusto Pasqualucci,Sérgio Rosemberg,Ricardo Nitrini,Paulo Hilário Nascimento Saldiva,Wilson Jacob Filho +8 more
TL;DR: The high percentage of non-demented subjects and the ethnic diversity of this series may be significantly contributive toward aging brain processes and related neurodegenerative diseases understanding since BBBABSG outcomes may provide investigators the answers to some additional questions.