Author
Josef Donnerer
Other affiliations: Austrian Academy of Sciences, Janssen Pharmaceutica, Roche Institute of Molecular Biology ...read more
Bio: Josef Donnerer is an academic researcher from Medical University of Graz. The author has contributed to research in topics: Substance P & Capsaicin. The author has an hindex of 39, co-authored 116 publications receiving 5089 citations. Previous affiliations of Josef Donnerer include Austrian Academy of Sciences & Janssen Pharmaceutica.
Papers published on a yearly basis
Papers
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TL;DR: Findings point towards a regulatory function for nerve growth factor in vivo in the stimulation of sensory neuropeptide synthesis during prolonged inflammatory processes.
575 citations
TL;DR: The results further support the concepts that neurogenic vasodilatation and plasma extravasation are mediated by SP, and that somatostatin and opiates inhibit the release of SP from peripheral sensory nerve endings.
250 citations
TL;DR: Findings point towards a regulatory function for nerve growth factor in vivo in the stimulation of sensory neuropeptide synthesis during prolonged inflammatory processes.
223 citations
TL;DR: Capsaicin (20-80 mg/kg, s.c.) reduced the inflammatory response to inoculation with Mycobacterium butyricum in the rat and attenuated the increase in substance P content in sciatic nerve, saphenous nerve, dorsal root ganglia, dorsal roots, and dorsal spinal cord which occurs in rats with adjuvant arthritis.
213 citations
TL;DR: Substance P was found to be increased in the sciatic nerve of rats suffering chronic pain due to adjuvant-induced polyarthritis, and this increase in primary afferents is assumed to reflect adaptive changes initiated by chronic noxious events such as inflammation.
198 citations
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TL;DR: The cloned capsaicin receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo.
Abstract: Capsaicin, the main pungent ingredient in 'hot' chilli peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system We have used an expression cloning strategy based on calcium influx to isolate a functional cDNA encoding a capsaicin receptor from sensory neurons This receptor is a non-selective cation channel that is structurally related to members of the TRP family of ion channels The cloned capsaicin receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo
8,186 citations
TL;DR: Rapid actions of neurotrophin-3 on synaptic efficacy, as well as the regulation of their mRNAs by electrical activity, suggest that neurotrophins might play important roles in regulating neuronal connectivity in the developing and in the adult central nervous system.
Abstract: The neurotrophins are a small group of dimeric proteins that profoundly affect the development of the nervous system of vertebrates. Recent studies have established clear correlations between the survival requirements for different neurotrophins of functionally distinct subsets of sensory neurons. The biological role of the neurotrophins is not limited to the prevention of programmed cell death of specific groups of neurons during development. Neurotrophin-3 in particular seems to act on neurons well before the period of target innervation and of normally occuning cell death. In animals lacking functional neurotrophin or receptor genes, neuronal numbers do not seem to be massively reduced in the CNS, unlike in the PNS. Finally, rapid actions of neurotrophins on synaptic efficacy, as well as the regulation of their mRNAs by electrical activity, suggest that neurotrophins might play important roles in regulating neuronal connectivity in the developing and in the adult central nervous system.
1,969 citations
TL;DR: A global account of mechanisms involved in the induction of pain is provided, including neuronal pathways for the transmission of nociceptive information from peripheral nerve terminals to the dorsal horn, and therefrom to higher centres.
1,752 citations
TL;DR: Etude du mecanisme d'action des neurones sensoriels et des fonctions de leurs effecteurs locaux en reponse a differents stimuli, au niveau des tissus directement en contact avec l'environnement exterieur.
1,685 citations
1,394 citations