Automated Anatomical Labeling of Activations in SPM Using a Macroscopic Anatomical Parcellation of the MNI MRI Single-Subject Brain

We explored the role of hypocretins in human narcolepsy through histopathology of six narcolepsy brains and mutation screening of Hcrt, Hcrtr1 and Hcrtr2 in 74 patients of various human leukocyte antigen and family history status. One Hcrt mutation, impairing peptide trafficking and processing, was found in a single case with early onset narcolepsy. In situ hybridization of the perifornical area and peptide radioimmunoassays indicated global loss of hypocretins, without gliosis or signs of inflammation in all human cases examined. Although hypocretin loci do not contribute significantly to genetic predisposition, most cases of human narcolepsy are associated with a deficient hypocretin system.

A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains

https://kclpure.kcl.ac.uk/portal/files/54999448/Catani_et_al_2002_Virtual_in_Vivo_Interactive_Dissection_of_White_Matter_Fasciculi_in_the_Human_Brain.pdf

Virtual in vivo interactive dissection of white matter fasciculi in the human brain

Prefrontal-subcortical pathways mediating successful emotion regulation.

Normal human behavior and cognition are reliant on a person’s ability to inhibit inappropriate thoughts, impulses, and actions. The temporal and spatial advantages of event-related functional MRI (fMRI) were exploited to identify cortical regions that showed a transient change in fMRI signal after the withholding of a prepotent motor response. The temporal specificity of the event-related fMRI design also minimized possible contamination from response inhibition errors (i. e., commission errors) and other extraneous processes. Regions identified were strongly lateralized to the right hemisphere and included the middle and inferior frontal gyri, frontal limbic area, anterior insula, and inferior parietal lobe. Contrary to the prominence traditionally given to ventral frontal regions for response inhibition, the results suggest that response inhibition is accomplished by a distributed cortical network.

/pdf/right-hemispheric-dominance-of-inhibitory-control-an-event-207m1o1vfs.pdf

Right hemispheric dominance of inhibitory control: An event-related functional MRI study

Material and methods topographic and topometric atlas myeloarchitectonic atlas hierarchical tree.

Joseph Assheuer

Papers

Atlas of the Human Brain