J
Joseph Cuschieri
Researcher at University of Washington
Publications - 155
Citations - 9523
Joseph Cuschieri is an academic researcher from University of Washington. The author has contributed to research in topics: Blunt trauma & Injury Severity Score. The author has an hindex of 46, co-authored 142 publications receiving 8231 citations. Previous affiliations of Joseph Cuschieri include University of California, San Francisco & University of Pittsburgh.
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Journal ArticleDOI
Genomic responses in mouse models poorly mimic human inflammatory diseases
Seok Junhee Seok,Shaw Warren,G. Cuenca Alex,N. Mindrinos Michael,V. Baker Henry,Weihong Xu,Daniel R. Richards,Grace P. McDonald-Smith,Hong Gao,Laura Hennessy,Celeste C. Finnerty,Cecilia M Lopez,Shari Honari,Ernest E. Moore,Joseph P. Minei,Joseph Cuschieri,Paul E. Bankey,Jeffrey L. Johnson,Jason L. Sperry,Avery B. Nathens,Timothy R. Billiar,Michael West,Marc G. Jeschke,Matthew B. Klein,Richard L. Gamelli,Nicole S. Gibran,Bernard H. Brownstein,Carol L. Miller-Graziano,Steve E. Calvano,Philip H. Mason,J. Perren Cobb,Laurence G. Rahme,Stephen F. Lowry,Ronald V. Maier,Lyle L. Moldawer,David N. Herndon,Ronald W. Davis,Wenzhong Xiao,Wenzhong Xiao,Ronald G. Tompkins +39 more
TL;DR: This study shows that, although acute inflammatory stresses from different etiologies result in highly similar genomic responses in humans, the responses in corresponding mouse models correlate poorly with the human conditions and also, one another.
Journal ArticleDOI
A genomic storm in critically injured humans
Wenzhong Xiao,Wenzhong Xiao,Michael N. Mindrinos,Junhee Seok,Joseph Cuschieri,Alex G. Cuenca,Hong Gao,Douglas L. Hayden,Laura Hennessy,Ernest E. Moore,Joseph P. Minei,Paul E. Bankey,Jeffrey L. Johnson,Jason L. Sperry,Avery B. Nathens,Timothy R. Billiar,Michael West,Bernard H. Brownstein,Philip H. Mason,Henry V. Baker,Celeste C. Finnerty,Marc G. Jeschke,M. Cecilia Lopez,Matthew B. Klein,Richard L. Gamelli,Nicole S. Gibran,Brett D. Arnoldo,Weihong Xu,Yuping Zhang,Steven E. Calvano,Grace P. McDonald-Smith,David A. Schoenfeld,John D. Storey,J. Perren Cobb,H. Shaw Warren,Lyle L. Moldawer,David N. Herndon,Stephen F. Lowry,Ronald V. Maier,Ronald W. Davis,Ronald G. Tompkins,W. Xiao,M. Mindrinos,J. Seok,J. Cuschieri,R. Tompkins,Roger J. Davis,R. Maier,L. Moldawer,L. Hennessy,E. Moore,J. Minei,P. Bankey,J. Johnson,J. Sperry,A. Nathens,T. Billiar,M. West,B. Brownstein,D. Herndon,H. Baker,C. Finnerty,M. Jeschke,M. Lopez,M. Klein,R. Gamelli,N. Gibran,B. Arnoldo,G. McDonald-Smith,D. Schoenfeld,J. P. Cobb,Shaw Warren,A. Cuenca,S. Lowry,S. Calvano,Doug Hayden,P. Mason,H. Gao,J. Storey,Lily L. Altstein,Ulysses J. Balis,David G. Camp,K. De Asit,Brian G. Harbrecht,Shari Honari,Bruce A. McKinley,Carol L. Miller-Graziano,Frederick A. Moore,Grant E. O'Keefe,Laurence G. Rahme,Daniel G. Remick,Michael B. Shapiro,Richard D. Smith,Robert Tibshirani,Mehmet Toner,Bram Wispelwey,Wing Hung Wong +96 more
TL;DR: It is shown that critical injury in humans induces a genomic storm with simultaneous changes in expression of innate and adaptive immunity genes that alter the status of these genes in the immune system.
Journal ArticleDOI
An FFP:PRBC transfusion ratio >/=1:1.5 is associated with a lower risk of mortality after massive transfusion.
Jason L. Sperry,Juan B. Ochoa,Scott R. Gunn,Louis H. Alarcon,Joseph P. Minei,Joseph Cuschieri,Matthew R. Rosengart,Ronald V. Maier,Timothy R. Billiar,Andrew B. Peitzman,Ernest E. Moore +10 more
TL;DR: In patients requiring>/=8 units of blood after serious blunt injury, an FFP:PRBC transfusion ratio >/=1:1.5 was associated with a significant lower risk of mortality but a higher risk of acute respiratory distress syndrome, providing further justification for the prospective trial investigation into the optimal FFP-PRBC ratio required in massive transfusion practice.
Journal ArticleDOI
Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome
Gregory A. Watson,Jason L. Sperry,Matthew R. Rosengart,Joseph P. Minei,Brian G. Harbrecht,Ernest E. Moore,Joseph Cuschieri,Ronald V. Maier,Timothy R. Billiar,Andrew B. Peitzman +9 more
TL;DR: In patients who survive their initial injury, FFP was independentlyassociated with a greater risk of developing MOF and ARDS, whereas CRYO was associated with a lower risk of MOF.
Journal ArticleDOI
The changing pattern and implications of multiple organ failure after blunt injury with hemorrhagic shock.
Joseph P. Minei,Joseph Cuschieri,Jason L. Sperry,Ernest E. Moore,Michael West,Brian G. Harbrecht,Grant E. O'Keefe,Mitchell J. Cohen,Lyle L. Moldawer,Ronald G. Tompkins,Ronald V. Maier +10 more
TL;DR: Standard operating procedure-driven interventions may be associated with a decrease in late multiple organ failure and morbidity, and Contrary to current paradigms, the onset is only early, and not bimodal, nor is it related with a “second-hit”-induced late onset.