J
Joseph Duggan
Researcher at Mater Misericordiae University Hospital
Publications - 46
Citations - 1796
Joseph Duggan is an academic researcher from Mater Misericordiae University Hospital. The author has contributed to research in topics: Population & Stroke. The author has an hindex of 22, co-authored 45 publications receiving 1650 citations. Previous affiliations of Joseph Duggan include Mater Misericordiae Hospital & Mater Health Services.
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Journal ArticleDOI
Connective tissue growth factor: Potential role in glomerulosclerosis and tubulointerstitial fibrosis
TL;DR: Observations identify CTGF as an attractive therapeutic target in fibrotic renal diseases because it augments the production of fibronectin and type IV collagen by Mesangial cells and the effects of high glucose on mesangial cell CTGF expression and matrix production are attenuated, in part, by anti-TGF-beta antibody.
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Stroke Associated with Atrial Fibrillation – Incidence and Early Outcomes in the North Dublin Population Stroke Study
Niamh Hannon,Orla Sheehan,Lisa A. Kelly,Michael Marnane,Aine Merwick,Alan Moore,Lorraine Kyne,Joseph Duggan,Joan T. Moroney,Patricia M.E. McCormack,Leslie Daly,Nicola Fitz-Simon,Dawn Harris,Gillian Horgan,Emma B. Williams,Karen L. Furie,Peter J. Kelly +16 more
TL;DR: AF-associated stroke occurred in one third of all patients and was associated with a distinct profile of recurrent, severe and disabling stroke, and targeted strategies to increase anticoagulation rates may provide a substantial benefit to prevent severe disabling stroke at a population level.
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Stroke Subtype Classification to Mechanism-Specific and Undetermined Categories by TOAST, A-S-C-O, and Causative Classification System Direct Comparison in the North Dublin Population Stroke Study
Michael Marnane,Caroline A. Duggan,Orla Sheehan,Aine Merwick,Niamh Hannon,Denis Curtin,Dawn Harris,Emma B. Williams,Gillian Horgan,Lorraine Kyne,Patricia M.E. McCormack,Joseph Duggan,Alan Moore,Gloria Crispino-O'Connell,Peter J. Kelly +14 more
TL;DR: Both CCS and ASCO schemes showed good-to-excellent agreement with TOAST, but each had specific characteristics compared with ToAST for subtype assignment and data retention.
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Population-Based Study of ABCD2 Score, Carotid Stenosis, and Atrial Fibrillation for Early Stroke Prediction After Transient Ischemic Attack. The North Dublin TIA Study
Orla Sheehan,Lorraine Kyne,Lisa A. Kelly,Niamh Hannon,Michael Marnane,Aine Merwick,Patricia M.E. McCormack,Joseph Duggan,Alan Moore,Joan T. Moroney,Leslie Daly,Dawn Harris,Gillian Horgan,Emma B. Williams,Peter J. Kelly +14 more
TL;DR: The ABCD2 score had predictive utility in patients with TIA suspected by nonspecialists, and low scores occurred in several patients with stroke recurrences, suggesting that caution is needed before using the score in isolation.
Journal ArticleDOI
Association Between Acute Statin Therapy, Survival, and Improved Functional Outcome After Ischemic Stroke The North Dublin Population Stroke Study
Danielle Ní Chróinín,Elizabeth Callaly,Joseph Duggan,Aine Merwick,Niamh Hannon,Orla Sheehan,Michael Marnane,Gillian Horgan,Emma B. Williams,Dawn Harris,Lorraine Kyne,Patricia M.E. McCormack,Joan T. Moroney,Tim Grant,David R. Williams,Leslie Daly,Peter J. Kelly +16 more
TL;DR: Statin therapy at stroke onset and newly begun statins were associated with improved early and late outcomes, supporting data from experimental studies, and randomized trials of statin therapy for treatment of acute stroke are needed.