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Joseph Edward Piel

Other affiliations: Mayo Clinic, GE Healthcare
Bio: Joseph Edward Piel is an academic researcher from General Electric. The author has contributed to research in topics: Radiofrequency coil & Electromagnetic coil. The author has an hindex of 13, co-authored 27 publications receiving 651 citations. Previous affiliations of Joseph Edward Piel include Mayo Clinic & GE Healthcare.

Papers
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Journal ArticleDOI
TL;DR: To determine whether the promise of high‐density many‐coil MRI receiver arrays for enabling highly accelerated parallel imaging can be realized in practice, a large number of experiments have been conducted with high-density receiver arrays in order to demonstrate the ability of these arrays to accommodate large numbers of patients.
Abstract: Purpose To determine whether the promise of high-density many-coil MRI receiver arrays for enabling highly accelerated parallel imaging can be realized in practice. Materials and Methods A 128-channel body receiver-coil array and custom MRI system were developed. The array comprises two clamshells containing 64 coils each, with the posterior array built to maximize signal-to-noise ratio (SNR) and the anterior array design incorporating considerations of weight and flexibility as well. Phantom imaging and human body imaging were performed using a variety of reduction factors and 2D and 3D pulse sequences. Results The ratio of SNR relative to a 32-element array of similar footprint was 1.03 in the center of an elliptical loading phantom and 1.7 on average in the outer regions. Maximum g-factors dropped from 5.5 (for 32 channels) to 2.0 (for 128 channels) for 4 × 4 acceleration and from 25 to 3.3 for 5 × 5 acceleration. Residual aliasing artifacts for a right/left (R/L) reduction factor of 8 in human body imaging were significantly reduced relative to the 32-channel array. Conclusion MRI with a large number of receiver channels enables significantly higher acceleration factors for parallel imaging and improved SNR, provided losses from the coils and electronics are kept negligible. J. Magn. Reson. Imaging 2008;28:1219–1225. © 2008 Wiley-Liss, Inc.

120 citations

Patent
21 May 2001
TL;DR: An incubator arrangement and a radiofrequency coil are provided for use in a Magnetic Resonance Imaging (MRI) system as mentioned in this paper, which comprises an enclosure adapted to support a subject in a magnet of the MRI system during imaging and disposed within the enclosure.
Abstract: An incubator arrangement and radiofrequency (RF) coil are provided for use in a Magnetic Resonance Imaging (MRI) system. The incubator arrangement comprises an enclosure adapted to support a subject in a magnet of the MRI system during imaging and a radiofrequency coil disposed within the enclosure. The RF coil is adapted to provide visual and physical access to the subject, and further adapted to obtain a selected signal to noise ratio.

74 citations

Journal ArticleDOI
TL;DR: To build and evaluate a small‐footprint, lightweight, high‐performance 3T MRI scanner for advanced brain imaging with image quality that is equal to or better than conventional whole‐body clinical3T MRI scanners, while achieving substantial reductions in installation costs.
Abstract: Purpose To build and evaluate a small-footprint, lightweight, high-performance 3T MRI scanner for advanced brain imaging with image quality that is equal to or better than conventional whole-body clinical 3T MRI scanners, while achieving substantial reductions in installation costs. Methods A conduction-cooled magnet was developed that uses less than 12 liters of liquid helium in a gas-charged sealed system, and standard NbTi wire, and weighs approximately 2000 kg. A 42-cm inner-diameter gradient coil with asymmetric transverse axes was developed to provide patient access for head and extremity exams, while minimizing magnet-gradient interactions that adversely affect image quality. The gradient coil was designed to achieve simultaneous operation of 80-mT/m peak gradient amplitude at a slew rate of 700 T/m/s on each gradient axis using readily available 1-MVA gradient drivers. Results In a comparison of anatomical imaging in 16 patients using T2 -weighted 3D fluid-attenuated inversion recovery (FLAIR) between the compact 3T and whole-body 3T, image quality was assessed as equivalent to or better across several metrics. The ability to fully use a high slew rate of 700 T/m/s simultaneously with 80-mT/m maximum gradient amplitude resulted in improvements in image quality across EPI, DWI, and anatomical imaging of the brain. Conclusions The compact 3T MRI system has been in continuous operation at the Mayo Clinic since March 2016. To date, over 200 patient studies have been completed, including 96 comparison studies with a clinical 3T whole-body MRI. The increased gradient performance has reliably resulted in consistently improved image quality.

69 citations

Patent
05 Apr 1990
TL;DR: In this article, a piezoelectric ultrasonic array transducer has its individual elements connected to external electronics via a high density interconnect structure which facilitates signal connection and uniformity from array-to-array.
Abstract: A piezoelectric ultrasonic array transducer has its individual elements connected to external electronics via a high density interconnect structure which facilitates signal connection and uniformity from array-to-array. The array fabrication process is preferably modified for use with a high density interconnect structure in order to obtain maximum transducer quality.

68 citations

Journal ArticleDOI
TL;DR: An incubator for magnetic resonance imaging (MRI) of premature and full-term infants was designed and constructed that will enable routine MRI scanning of newborn infants requiring extensive monitoring of vital signs and/or temperature regulation.
Abstract: An incubator for magnetic resonance imaging (MRI) of premature and full-term infants was designed and constructed The device is an extensively modified MRI system table that has a permanently attached incubator housing, self-contained power supply, and full patient monitoring capability A custom eight-element birdcage coil within the incubator slides over the infant and provides high sensitivity for MRI The incubator provides all the temperature control and patient monitoring found in conventional neonatal intensive care incubators, but in an MRI-compatible fashion The table can operate for at least three hours on a single battery charge It is believed that this table design will enable routine MRI scanning of newborn infants requiring extensive monitoring of vital signs and/or temperature regulation © 2002 Wiley Periodicals, Inc Concepts in Magnetic Resonance (Magn Reson Engineering) 15: 117–128, 2002

62 citations


Cited by
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Journal ArticleDOI
TL;DR: Recognition of at-risk newborns by means of advanced methods of neuroimaging, combined with a plan for rational intervention, may result in the prevention or the reduction in the incidence of lifelong disabilities such as cerebral palsy, epilepsy, and behavioral and learning disorders.
Abstract: More than 95 percent of infants who have neonatal stroke survive to adulthood, and many have residual motor or cognitive disabilities. This article makes the point that recognition of at-risk newborns by means of advanced methods of neuroimaging, combined with a plan for rational intervention, may result in the prevention or the reduction in the incidence of lifelong disabilities such as cerebral palsy, epilepsy, and behavioral and learning disorders.

1,111 citations

Journal ArticleDOI
TL;DR: This first-in-man imaging study evaluated the safety and feasibility of hyperpolarized [1-13C]pyruvate as an agent for noninvasively characterizing alterations in tumor metabolism for patients with prostate cancer and showed elevated levels of lactate, alanine, and bicarbonate in regions of biopsy-proven cancer.
Abstract: This first-in-man imaging study evaluated the safety and feasibility of hyperpolarized [1-13C]pyruvate as an agent for noninvasively characterizing alterations in tumor metabolism for patients with prostate cancer. Imaging living systems with hyperpolarized agents can result in more than 10,000-fold enhancement in signal relative to conventional magnetic resonance (MR) imaging. When combined with the rapid acquisition of in vivo 13C MR data, it is possible to evaluate the distribution of agents such as [1-13C]pyruvate and its metabolic products lactate, alanine, and bicarbonate in a matter of seconds. Preclinical studies in cancer models have detected elevated levels of hyperpolarized [1-13C]lactate in tumor, with the ratio of [1-13C]lactate/[1-13C]pyruvate being increased in high-grade tumors and decreased after successful treatment. Translation of this technology into humans was achieved by modifying the instrument that generates the hyperpolarized agent, constructing specialized radio frequency coils to detect 13C nuclei, and developing new pulse sequences to efficiently capture the signal. The study population comprised patients with biopsy-proven prostate cancer, with 31 subjects being injected with hyperpolarized [1-13C]pyruvate. The median time to deliver the agent was 66 s, and uptake was observed about 20 s after injection. No dose-limiting toxicities were observed, and the highest dose (0.43 ml/kg of 230 mM agent) gave the best signal-to-noise ratio for hyperpolarized [1-13C]pyruvate. The results were extremely promising in not only confirming the safety of the agent but also showing elevated [1-13C]lactate/[1-13C]pyruvate in regions of biopsy-proven cancer. These findings will be valuable for noninvasive cancer diagnosis and treatment monitoring in future clinical trials.

1,054 citations

Journal ArticleDOI
TL;DR: This document was approved by the American College of Cardiology Foundation Board of Trustees in May 2003, byThe American Heart Association Science Advisory and Coordinating Committee in May2003, and by theAmerican Society of Echocardiography Board of Directors in May 2002.

825 citations

Journal ArticleDOI
TL;DR: The imaging findings in term newborns with congenital heart disease are similar to those in premature newborns and may reflect abnormal brain development in utero.
Abstract: Results As compared with control newborns, those with congenital heart disease had a decrease of 10% in the ratio of N-acetylaspartate to choline (P = 0.003), an increase of 28% in the ratio of lactate to choline (P = 0.08), an increase of 4% in average diffusivity (P<0.001), and a decrease of 12% in white-matter fractional anisotropy (P<0.001). Preoperative brain injury, as seen on MRI, was not significantly associated with findings on MRS or DTI. White-matter injury was observed in 13 newborns with congenital heart disease (32%) and in no control newborns. Conclusions Term newborns with congenital heart disease have widespread brain abnormalities before they undergo cardiac surgery. The imaging findings in such newborns are similar to those in premature newborns and may reflect abnormal brain development in utero.

735 citations