J
Joseph El Khoury
Researcher at Harvard University
Publications - 75
Citations - 16570
Joseph El Khoury is an academic researcher from Harvard University. The author has contributed to research in topics: Microglia & Scavenger receptor. The author has an hindex of 42, co-authored 71 publications receiving 13065 citations. Previous affiliations of Joseph El Khoury include Albert Einstein College of Medicine & Columbia University.
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Journal ArticleDOI
Neuroinflammation in Alzheimer's disease
Michael T. Heneka,Monica J. Carson,Joseph El Khoury,Gary E. Landreth,Frederic Brosseron,Douglas L. Feinstein,Andreas H. Jacobs,Tony Wyss-Coray,Tony Wyss-Coray,Javier Vitorica,Richard M. Ransohoff,Karl Herrup,Sally A. Frautschy,Bente Finsen,Guy C. Brown,Alexei Verkhratsky,Alexei Verkhratsky,Alexei Verkhratsky,Koji Yamanaka,Jari Koistinaho,Eicke Latz,Eicke Latz,Annett Halle,Gabor C. Petzold,Terrence Town,Dave Morgan,Mari L. Shinohara,V. Hugh Perry,Clive Holmes,Clive Holmes,Nicolas G. Bazan,David J. Brooks,Stéphane Hunot,Bertrand Joseph,Nikolaus Deigendesch,Olga Garaschuk,Erik Boddeke,Charles A. Dinarello,John C.S. Breitner,Greg M. Cole,Douglas T. Golenbock,Markus P. Kummer +41 more
TL;DR: Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded proteins and the inflammatory reaction.
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CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer
Cameron R. Stewart,Lynda M. Stuart,Kim Wilkinson,Janine M. van Gils,Jiusheng Deng,Annett Halle,Annett Halle,Katey J. Rayner,Laurent Boyer,Ruiqin Zhong,William A. Frazier,Adam Lacy-Hulbert,Joseph El Khoury,Douglas T. Golenbock,Kathryn J. Moore,Kathryn J. Moore +15 more
TL;DR: It is shown that oxidized LDL and amyloid-β trigger inflammatory signaling through a heterodimer of Toll-like receptors 4 and 6 that is regulated by signals from the scavenger receptor CD36, a common receptor for these disparate ligands.
Journal ArticleDOI
The microglial sensome revealed by direct RNA sequencing
Suzanne E. Hickman,Nathan D. Kingery,Toshiro K. Ohsumi,Mark L. Borowsky,Li-chong Wang,Terry K. Means,Joseph El Khoury +6 more
TL;DR: It is found that microglia have a distinct transcriptomic signature and express a unique cluster of transcripts encoding proteins for sensing endogenous ligands and microbes that are referred to as the sensome and aging was associated with an overall increase in the expression of microglial genes involved in neuroprotection.
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Microglial dysfunction and defective β-amyloid clearance pathways in aging Alzheimer’s disease mice
TL;DR: Although early microglial recruitment promotes Aβ clearance and is neuroprotective in AD, as disease progresses, proinflammatory cytokines produced in response to Aβ deposition downregulate genes involved in A β clearance and promote Aβ accumulation, therefore contributing to neurodegeneration.
Journal ArticleDOI
Microglia in neurodegeneration.
TL;DR: The immune checkpoints that control microglial functions are considered and how their imbalance and subsequent neuroinflammation leads to neurodegeneration is discussed.