Showing papers by "Joseph L. Izzo published in 1961"

Comparative effects of glucagon, hydrocortisone and epinephrine on the protein metabolism of the fasting rat.

Abstract: An approach toward the elucidation of the mechanism of action of gluoagon in promoting protein catabolism has been made by comparing the metabolic effects of glucagon and hydrocortisone using female rats fasted five days. The possible relationship of the level of liver glycogen to protein catabolism has also been investigated by comparing the action of glucagon and epinephrine. Both glucagon and hydrocortisone-treated animals lost more weight and excreted more urinary nitrogen, phosphorus and creatinine than controls. The rate of nitrogen and phosphorus excretion of glucagon-treated rats declined progressively whereas that of hydrocortisone-treated rats increased progressively throughout the course of the experiment. Although the animals in both groups lost similar amounts of urinary nitrogen the glucagon-treated rats lost less body weight, tissue protein and urinary phosphorus. Furthermore, hydrocortisone caused an elevation in the level of blood a amino nitrogen whereas glucagon caused blood a amino nit...