J
Joseph P. Y. Kao
Researcher at University of Maryland, Baltimore
Publications - 157
Citations - 9534
Joseph P. Y. Kao is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Electron paramagnetic resonance & Auditory cortex. The author has an hindex of 38, co-authored 144 publications receiving 8995 citations. Previous affiliations of Joseph P. Y. Kao include University of Maryland, College Park & University of Maryland Biotechnology Institute.
Papers
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Journal ArticleDOI
Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores.
TL;DR: A new group of fluorescent indicators with visible excitation and emission wavelengths has been synthesized for measurements of cytosolic free Ca2+.
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Photochemically generated cytosolic calcium pulses and their detection by fluo-3.
TL;DR: It is demonstrated that fluo-3 can be loaded into fibroblasts and lymphocytes by incubation with the pentaacetoxymethyl ester of the dye and that the ester is hydrolyzed intracellularly to yield genuine flui-3 capable of indicating changes in [Ca2+]i induced by agonist stimulation.
Journal ArticleDOI
Superoxide Flashes in Single Mitochondria
Wang Wang,Huaqiang Fang,Linda Groom,Aiwu Cheng,Wanrui Zhang,Jie Liu,Xianhua Wang,Kaitao Li,Peidong Han,Ming Zheng,Jinhu Yin,Weidong Wang,Mark P. Mattson,Joseph P. Y. Kao,Edward G. Lakatta,Shey-Shing Sheu,Kunfu Ouyang,Ju Chen,Robert T. Dirksen,Heping Cheng +19 more
TL;DR: It is shown that individual mitochondria undergo spontaneous bursts of superoxide generation, termed "superoxide flashes", and proposed that superoxide flashes could serve as a valuable biomarker for a wide variety of oxidative stress-related diseases.
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Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers.
TL;DR: The results suggest that surfactants can inhibit multiple transporters but that changes in membrane fluidity may not be a generalized mechanism to reduce transporter activity.
Journal ArticleDOI
Fluorescence ratio imaging of cytosolic free Na+ in individual fibroblasts and lymphocytes.
Alec Tate Harootunian,Alec Tate Harootunian,Joseph P. Y. Kao,Joseph P. Y. Kao,Barbara Eckert,Barbara Eckert,Roger Y. Tsien,Roger Y. Tsien +7 more
TL;DR: As expected, large increases in [Na+]i were elicited by blocking the Na+ pump with ouabain or withdrawal of extracellular K+.