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Joseph Puglis

Bio: Joseph Puglis is an academic researcher. The author has contributed to research in topics: Nucleophile & Sulfonate. The author has an hindex of 1, co-authored 1 publications receiving 114 citations.


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Journal ArticleDOI
TL;DR: A new stereoselective synthesis of 2′-C-methyluridine is expected to generate RNA analogues potentially useful in applications where proper RNA folding is required since the 2-hydroxyl group is conserved.

77 citations

Journal ArticleDOI
TL;DR: N-Heterocyclic carbene-borane complexes such as depicted are neutral, organic soluble analogues of borohydride anions with a weak hydridic character compatible with organometallic catalysis, applicable for surgical reductions in complex, multifunctional molecules.
Abstract: Surgical reduction: N-Heterocyclic carbene-borane complexes such as depicted are neutral, organic soluble analogues of borohydride anions with a weak hydridic character, compatible with organometallic catalysis. They are applicable for surgical reductions in complex, multifunctional molecules. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

77 citations

Journal ArticleDOI
TL;DR: In this paper, allylic acetates are reduced to alkenes by reductive displacement by hydride reagents via catalytic activation with Pd(0) complexes.

68 citations

Journal ArticleDOI
TL;DR: In this article, the authors present a review of the use of NICKEL BORIDE in the context of organic preparation and procedures, and present a discussion of the most useful reactions with it.

61 citations

Journal ArticleDOI
TL;DR: In this paper, the reduction of carbonyl compounds such as aldehydes, ketones, conjugated enones, acyloins, and α-diketones to their corresponding alcohols was performed at room temperature or under reflux condition.
Abstract: NaBH 4 in wet THF can readily reduce varieties of carbonyl compounds such as aldehydes, ketones, conjugated enones, acyloins, and α-diketones to their corresponding alcohols in good to excellent yields. Reduction reactions were performed at room temperature or under reflux condition. In addition, the chemoselective reduction of aldehydes over ketones was accomplished successfully with this reducing system.

48 citations