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Joseph S. Fruton

Other affiliations: Rockefeller University
Bio: Joseph S. Fruton is an academic researcher from Yale University. The author has contributed to research in topics: Proteolytic enzymes & Pepsin. The author has an hindex of 45, co-authored 175 publications receiving 6572 citations. Previous affiliations of Joseph S. Fruton include Rockefeller University.


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TL;DR: Although his studies on immune reactions and on chemotherapy came after 1890, the earlier work was no less important, since it included his research on the use of aniline dyes for hematological and bacteriological staining, for the study of biochemical reactions, and for the examination of pathological tissues and fluids.
Abstract: This important volume is the first of four; the second will deal with Ehrlich's work on immunology and cancer, the third with his studies in chemotherapy, and the fourth, in addition to a bibliography and indexes, will contain tributes by Ehrlich to his teachers, supporters, and colleagues. The papers collected in the first volume describe work done by Ehrlich during the period 1877-1890, as a university student, as a young hospital physician, and as a free-lance laboratory worker. Although his studies on immune reactions and on chemotherapy, which brought Ehrlich world-wide fame, came after 1890, the earlier work was no less important, since it included his research on the use of aniline dyes for hematological and bacteriological staining, for the study of biochemical reactions, and for the examination of pathological tissues and fluids. The exceptional imagination that characterized Ehrlich's scientific thought is evident throughout this volume, and is nowhere clearer than in his previously unpublished doctoral dissertation of 1878: \"Beitrage zur Theorie und Praxis der histologischen Farbung\" (an English translation is also included). Written when Ehrlich was 24 years old, the dissertation contains the germs of many of the ideas he was to pursue until his death in 1915. For the student of the history of science, this dissertation has special interest; it underlines Ehrlich's role in the application, to biological studies, of the experience gained by the dyers of textiles in their use of the newly developed aniline dyes. By 1877, Germany had initiated the development of an active dyestuff industry and also took the lead in the synthesis of new dyes. After his doctorate, Ehrlich concentrated on the development of improved procedures for the staining of tissues, of blood cells, and of bacteria. From these studies, he moved to an examination of the capacity of biological systems to reduce dyes and to re-oxidize reduced dyes in the presence of oxygen. This volume contains Ehrlich's memorable paper of 1885 on \"Das Sauerstoff-Bediirfnis des Organismus\" (also with an English translation), which foreshadows ideas that emerged more clearly from the later work of Battelli and Stern (ca. 1910), of Thunberg (ca. 1920), and of Keilin (ca. 1926). The influence that Ehrlich's early studies had on his followers, especially on Leonor Michaelis (1875-1949), is striking. The volume is made even more valuable by an affectionate introduction by Sir Henry Dale. The format is most attractive, and the editing appears to have been done with exemplary care. The publication of all four volumes is made possible by the enlightened philanthropy of The Wellcome Trust. The editors, the sponsors, and the publishers are to be congratulated on having given to the world of science this splendid addition to its historical literature, and so appropriate a tribute to the greatness of Paul Ehrlich.

344 citations

Journal Article
TL;DR: It's important for you to start having that hobby that will lead you to join in better concept of life and reading will be a positive activity to do every time.
Abstract: methods of biochemical analysis What to say and what to do when mostly your friends love reading? Are you the one that don't have such hobby? So, it's important for you to start having that hobby. You know, reading is not the force. We're sure that reading will lead you to join in better concept of life. Reading will be a positive activity to do every time. And do you know our friends become fans of methods of biochemical analysis as the best book to read? Yeah, it's neither an obligation nor order. It is the referred book that will not make you feel disappointed.

271 citations


Cited by
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TL;DR: Compounds Used-N”l-Acetyl-n-ornithine was synthesized as previously described and L-Ornithine monohydrochloride was obtained from the Mann Research Laboratories.

4,028 citations

Journal ArticleDOI
TL;DR: Preliminary studies indicate that benzoyl dl -arginine p -nitroanilide hydrochloride is also hydrolyzed by papain, and that of l -LPA is in a more alkaline region than normally found for trypsin substrates.

3,118 citations

Journal ArticleDOI
TL;DR: Delivery of conventional chemotherapeutic anti-cancer drugs is mainly discussed and exploitation and the understanding of these characteristics to design new drug delivery systems targeting the tumor are focused on.

2,272 citations

Journal ArticleDOI
TL;DR: The spectrophotometric procedure proposed by Schwert and Takenaka has been modified and extended to include the application to N-benzoyl-L-tyrosine ethyl ester and α-p-toluenesulphonyl- L-arginine methyl ester, allowing the determination of traces of chymotrypsin in the presence of relatively large amounts of trypsin.
Abstract: The spectrophotometric procedure proposed by Schwert and Takenaka for the assay of chymotrypsin and trypsin has been modified and extended to include the application to N-benzoyl-L-tyrosine ethyl e...

1,706 citations