J
Joseph Sodroski
Researcher at Harvard University
Publications - 551
Citations - 80179
Joseph Sodroski is an academic researcher from Harvard University. The author has contributed to research in topics: Virus & Glycoprotein. The author has an hindex of 138, co-authored 542 publications receiving 77070 citations. Previous affiliations of Joseph Sodroski include Massachusetts Institute of Technology & Southern Research Institute.
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Journal ArticleDOI
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody
Peter D. Kwong,Richard T. Wyatt,James E. Robinson,Raymond W. Sweet,Joseph Sodroski,Wayne A. Hendrickson,Wayne A. Hendrickson +6 more
TL;DR: The structure reveals a cavity-laden CD4–gp120 interface, a conserved binding site for the chemokine receptor, evidence for a conformational change upon CD4 binding, the nature of a CD4-induced antibody epitope, and specific mechanisms for immune evasion.
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The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates
Hyeryun Choe,Michael Farzan,Ying Sun,Nancy Sullivan,Barrett J. Rollins,Paul D. Ponath,Lijun Wu,Charles R. Mackay,Gregory J. LaRosa,Walter Newman,Norma P. Gerard,Craig Gerard,Joseph Sodroski +12 more
TL;DR: The ability of various members of the chemokine receptor family to support the early stages of HIV-1 infection helps to explain viral tropism and beta-chemokine inhibition of primary HIV- 1 isolates.
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The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry.
Conrad C. Bleul,Michael Farzan,Hyeryun Choe,Cristina Parolin,Cristina Parolin,Ian Clark-Lewis,Joseph Sodroski,Timothy A. Springer +7 more
TL;DR: Testing of potential receptors demonstrated that SDF-1 signalled through, and hence 'adopted', the orphan receptor LESTR, which is therefore designated CXC-chemokine receptor-4 (CXCR-4).
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The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys.
Matthew Stremlau,Christopher M. Owens,Michel Perron,Michael Kiessling,Patrick Autissier,Joseph Sodroski +5 more
TL;DR: Host cell barriers to the early phase of immunodeficiency virus replication explain the current distribution of these viruses among human and non-human primate species and reveal host cell components that modulate the uncoating of a retroviral capsid.
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The HIV-1 envelope glycoproteins: fusogens, antigens, and immunogens.
Richard T. Wyatt,Joseph Sodroski +1 more
TL;DR: The human immunodeficiency virus-type 1 (HIV-1) envelope glycoproteins interact with receptors on the target cell and mediate virus entry by fusing the viral and cell membranes.