J
Joseph T. Rodgers
Researcher at University of Southern California
Publications - 34
Citations - 11353
Joseph T. Rodgers is an academic researcher from University of Southern California. The author has contributed to research in topics: Stem cell & Mitochondrion. The author has an hindex of 24, co-authored 34 publications receiving 10309 citations. Previous affiliations of Joseph T. Rodgers include Stanford University & Johns Hopkins University.
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Journal ArticleDOI
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.
Joseph T. Rodgers,Carlos Lerin,Wilhelm Haas,Steven P. Gygi,Bruce M. Spiegelman,Pere Puigserver +5 more
TL;DR: It is shown that the Sir2 homologue, SIRT1 controls the gluconeogenic/glycolytic pathways in liver in response to fasting signals through the transcriptional coactivator PGC-1α, and this findings have strong implications for the basic pathways of energy homeostasis, diabetes and lifespan.
Journal ArticleDOI
mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex
John T. Cunningham,Joseph T. Rodgers,Daniel H. Arlow,Francisca Vazquez,Vamsi K. Mootha,Pere Puigserver,Pere Puigserver +6 more
TL;DR: A mechanism by which a nutrient sensor (mTOR) balances energy metabolism by means of the transcriptional control of mitochondrial oxidative function is identified, which has important implications for the understanding of how these pathways might be altered in metabolic diseases and cancer.
Journal ArticleDOI
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α
Zachary Gerhart-Hines,Zachary Gerhart-Hines,Joseph T. Rodgers,Joseph T. Rodgers,Olivia Bare,Carles Lerin,Carles Lerin,Seung hee Kim,Seung hee Kim,Raul Mostoslavsky,Frederick W. Alt,Zhidan Wu,Pere Puigserver,Pere Puigserver +13 more
TL;DR: SIRT1 is identified as a functional regulator of PGC‐1α that induces a metabolic gene transcription program of mitochondrial fatty acid oxidation in response to low glucose concentrations and has implications for understanding selective nutrient adaptation and how it might impact lifespan or metabolic diseases such as obesity and diabetes.
Journal ArticleDOI
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.
Dohoon Kim,Dohoon Kim,Minh Dang Nguyen,Matthew M. Dobbin,Andre Fischer,Farahnaz Sananbenesi,Joseph T. Rodgers,Joseph T. Rodgers,Ivana Delalle,Joseph A. Baur,Guangchao Sui,Sean M. Armour,Pere Puigserver,Pere Puigserver,David A. Sinclair,Li-Huei Tsai +15 more
TL;DR: It is reported that a human homologue of SIR2, SIRT1, is upregulated in mouse models for AD, ALS and in primary neurons challenged with neurotoxic insults, and provides a promising avenue for therapeutic intervention.
Journal ArticleDOI
Neuronal SIRT1 Activation as a Novel Mechanism Underlying the Prevention of Alzheimer Disease Amyloid Neuropathology by Calorie Restriction
Weiping Qin,Tianle Yang,Lap Ho,Lap Ho,Zhong Zhao,Jun Wang,Linghong Chen,Wei Zhao,Meenakshisundaram Thiyagarajan,Donal MacGrogan,Joseph T. Rodgers,Pere Puigserver,Junichi Sadoshima,Haiteng Deng,Steven Pedrini,Sam Gandy,Anthony A. Sauve,Giulio Maria Pasinetti,Giulio Maria Pasinetti +18 more
TL;DR: The predicted attenuation ofβ-amyloid content in the brain during CR can be reproduced in mouse neurons in vitro by manipulating cellular SIRT1 expression/activity through mechanisms involving the regulation of the serine/threonine Rho kinase ROCK1.